Info
| ID | 163 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | Ru5 |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].[c-]1n(Cc2ccccc2)cc[n+]1C1=NC2C=CC=CC2S1 |
TUCAN
C27H29N3RuS/(1-52)(2-52)(3-33)(4-49)(5-31)(6-39)(7-31)(8-40)(9-50)(10-34)(11-42)(12-45)(13-36)(14-35)(15-43)(16-37)(17-41)(18-51)(19-53)(20-55)(21-31)(22-30)(23-30)(24-32)(25-38)(26-32)(27-30)(28-44)(29-32)(30-46)(31-49)(32-49)(33-36)(33-42)(34-37)(34-43)(35-36)(35-45)(37-53)(38-39)(38-46)(39-47)(40-44)(40-47)(41-43)(41-55)(42-48)(44-46)(45-48)(47-49)(48-52)(50-51)(50-57)(51-58)(52-58)(53-55)(53-59)(54-57)(54-58)(55-60)(56-57)(56-59)(56-60)(59-61)(60-61)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 6.6 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HT-29 | 8.5 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HCT-116 | 44 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| HeLa | 56 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| LoVo | 57 | — | 10.1016/j.ejmech.2020.112605 | 2020 |
| A549 | — | — | 10.1016/j.ejmech.2020.112605 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Ru4 and Ru6 complexes induced apoptosis in a caspase-dependent manner, primarily through intracellular reactive oxygen species (ROS) overproduction and cell cycle arrest at G1 phase.»