Info
| ID | 977 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6, "S": 1} |
| Abbreviation | Ru3 |
| SMILES | C[C@@H]1CC[C@]2(C(=O)N3CCN(C(=S)[S-])CC3)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C2[C@H]1C.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C83H87N6O2RuS2/(1-131)(2-96)(3-97)(4-156)(5-104)(6-98)(7-99)(8-100)(9-95)(10-108)(11-101)(12-118)(13-92)(14-103)(15-92)(16-157)(17-102)(18-105)(19-158)(20-91)(21-149)(22-106)(23-120)(24-147)(25-92)(26-94)(27-160)(28-160)(29-89)(30-89)(31-90)(32-90)(33-129)(34-150)(35-90)(36-93)(37-93)(38-93)(39-128)(40-123)(41-125)(42-126)(43-124)(44-163)(45-161)(46-130)(47-126)(48-161)(49-148)(50-128)(51-129)(52-131)(53-130)(54-162)(55-163)(56-89)(57-125)(58-94)(59-94)(60-159)(61-107)(62-111)(63-114)(64-113)(65-110)(66-112)(67-127)(68-88)(69-146)(70-162)(71-168)(72-91)(73-116)(74-115)(75-109)(76-121)(77-119)(78-117)(79-91)(80-122)(81-127)(82-132)(83-88)(84-88)(85-124)(86-132)(87-178)(88-146)(89-151)(90-154)(91-149)(92-155)(93-154)(94-153)(95-96)(95-102)(96-135)(97-101)(97-135)(98-100)(98-134)(99-103)(99-139)(100-136)(101-102)(103-107)(104-133)(104-156)(105-140)(105-157)(106-141)(106-158)(107-110)(108-110)(108-139)(109-112)(109-115)(111-112)(111-142)(113-145)(113-159)(114-115)(114-142)(116-117)(116-143)(117-121)(118-120)(118-138)(119-122)(119-143)(120-144)(121-122)(123-128)(123-137)(124-127)(124-146)(125-126)(125-151)(126-152)(127-152)(128-148)(129-131)(129-150)(130-132)(130-153)(131-155)(132-168)(133-134)(133-135)(134-164)(136-140)(136-165)(137-147)(137-151)(138-141)(138-166)(139-140)(141-142)(143-145)(144-145)(144-167)(146-149)(147-149)(147-152)(148-153)(148-155)(150-153)(150-154)(151-155)(152-169)(154-168)(156-173)(157-174)(158-175)(159-176)(160-161)(160-171)(161-172)(162-163)(162-172)(163-171)(164-165)(164-173)(165-174)(166-167)(166-175)(167-176)(168-178)(169-172)(169-177)(170-171)(170-179)(170-180)(173-181)(174-181)(175-181)(176-181)(178-181)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 2.6 | — | 10.1093/mtomcs/mfac072 | 2022 |
| MDA-MB-231 | 5.5 | — | 10.1093/mtomcs/mfac072 | 2022 |
| MGC-803 | 10 | — | 10.1093/mtomcs/mfac072 | 2022 |
| MCF-7 | 15 | — | 10.1093/mtomcs/mfac072 | 2022 |
| HepG2 | 41 | — | 10.1093/mtomcs/mfac072 | 2022 |
| CNE-2 | — | — | 10.1093/mtomcs/mfac072 | 2022 |
🧬 Cell Death Types (1)
Necroptosis
high
«Mitochondrial swelling resulted in vacuolization, which induced vacuolation-associated cell death and necroptosis with the formation of necrosomes (RIP1-RIP3) and the uptake of propidium iodide.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
Loading source metadata…
The generated SVG will appear here. The legacy ligand image above stays visible for side-by-side review.