Info
| ID | 97 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3, "S": 1, "P": 2} |
| Abbreviation | Ru3 |
| SMILES | N=c1cc(N)nc([S-])[nH]1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccn2)cc1 |
TUCAN
C49H47N5P3RuS/(1-51)(2-66)(3-57)(4-49)(5-52)(6-55)(7-56)(8-60)(9-70)(10-50)(11-82)(12-61)(13-72)(14-84)(15-53)(16-59)(17-64)(18-87)(19-62)(20-63)(21-69)(22-87)(23-88)(24-88)(25-65)(26-67)(27-82)(28-76)(29-77)(30-68)(31-83)(32-80)(33-54)(34-58)(35-71)(36-78)(37-83)(38-74)(39-73)(40-81)(41-75)(42-48)(43-79)(44-98)(45-99)(46-97)(47-97)(48-49)(48-95)(49-53)(50-60)(50-66)(51-52)(51-89)(52-57)(53-84)(54-55)(54-89)(55-57)(56-58)(56-72)(58-92)(59-61)(59-66)(60-90)(61-90)(62-64)(62-91)(63-65)(63-91)(64-70)(65-70)(67-69)(67-76)(68-85)(68-86)(69-93)(71-72)(71-73)(73-92)(74-76)(74-77)(75-78)(75-80)(77-93)(78-79)(79-81)(80-94)(81-94)(82-83)(82-87)(83-88)(84-100)(85-97)(85-101)(86-98)(86-99)(87-102)(88-104)(89-103)(90-102)(91-102)(92-103)(93-104)(94-104)(95-100)(95-103)(96-98)(96-101)(96-105)(99-106)(100-106)(101-106)(102-106)(103-106)(104-106)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.36 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| MCF-10A | 0.58 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| A549 | 1.8 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| MRC-5 | 3.7 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the compound induces cell death by an apoptotic pathway in a dose-dependent manner, according to annexin V-PE assay.»