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Complex #964 — Ru(2) [TolRuCl]

2D Structure

Structure
⬇ MOL V3000

Info

ID964
MetalRu
Oxidation state2
Charge1
Donor atoms—
AbbreviationTolRuCl
SMILESCc1c(C)c(C)[c-](C)c1C.Cc1ccccc1

TUCAN

C17Ru/(1-12)(2-13)(3-14)(4-15)(5-16)(6-17)(7-8)(7-14)(8-9)(9-11)(10-11)(10-14)(12-13)(12-15)(13-16)(15-17)(16-17)

Measurements (41)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MM96L2.3— 10.1002/asia.201100637 2012
MM96L2.3— 10.1021/ic801159f 2008
CI80-13S3.9— 10.1002/asia.201100637 2012
MM96L4.5— 10.1021/ic801159f 2008
MM96L4.6— 10.1021/ic801159f 2008
MCF-75— 10.1002/asia.201100637 2012
MCF-75— 10.1021/ic801159f 2008
T47D5.2— 10.1002/asia.201100637 2012
MDA-MB-2315.2— 10.1002/asia.201100637 2012
MDA-MB-2315.2— 10.1021/ic801159f 2008
MM418c56.3— 10.1002/asia.201100637 2012
DU-1458.2— 10.1002/asia.201100637 2012
MCF-78.6— 10.1021/ic801159f 2008
PC-38.8— 10.1002/asia.201100637 2012
HT-299.8— 10.1002/asia.201100637 2012
B1612— 10.1002/asia.201100637 2012
A54913— 10.1002/asia.201100637 2012
MCF-714— 10.1021/ic801159f 2008
MDA-MB-23114— 10.1021/ic801159f 2008
RAW 264.717— 10.1002/asia.201100637 2012
MDA-MB-23121— 10.1021/ic801159f 2008
A278030— 10.1002/cplu.202000022 2020
A278040— 10.1002/cplu.202000022 2020
MDA-MB-23142— 10.1002/cplu.202000022 2020
HEK29343— 10.1002/cplu.202000022 2020
HEK29356— 10.1002/cplu.202000022 2020
MDA-MB-23173— 10.1002/cplu.202000022 2020
NFF92— 10.1002/asia.201100637 2012
NFF92— 10.1021/ic801159f 2008
HEK2931.4e+02— 10.1002/cplu.202000022 2020
HEK2931.4e+02— 10.1002/cplu.202000022 2020
NFF1.6e+02— 10.1021/ic801159f 2008
NFF1.6e+02— 10.1021/ic801159f 2008
SK-OV-3—— 10.1002/cplu.202000022 2020
SK-OV-3—— 10.1002/cplu.202000022 2020
A2780—— 10.1002/cplu.202000022 2020
A2780—— 10.1002/cplu.202000022 2020
SK-OV-3—— 10.1002/cplu.202000022 2020
SK-OV-3—— 10.1002/cplu.202000022 2020
MDA-MB-231—— 10.1002/cplu.202000022 2020
MDA-MB-231—— 10.1002/cplu.202000022 2020

🧬 Cell Death Types (1)

Apoptosis high
«The induction of apoptosis was investigated using Annexin V/PI staining... Both compounds (4 and 6) induced apoptosis in breast cancer cells MDA-MB-231 with similar intensity.»

Source-assisted 2D generator

Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.

experimental validation surface
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