Info
| ID | 96 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"S": 1, "N": 3, "P": 3} |
| Abbreviation | Ru2 |
| SMILES | [S-]c1ncccn1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccn2)cc1 |
TUCAN
C49H45N3P3RuS/(1-50)(2-52)(3-72)(4-55)(5-49)(6-57)(7-80)(8-60)(9-48)(10-82)(11-46)(12-51)(13-47)(14-80)(15-64)(16-54)(17-56)(18-81)(19-62)(20-65)(21-68)(22-66)(23-81)(24-67)(25-58)(26-85)(27-85)(28-77)(29-59)(30-83)(31-75)(32-84)(33-86)(34-61)(35-69)(36-53)(37-70)(38-78)(39-86)(40-63)(41-73)(42-76)(43-74)(44-71)(45-79)(46-72)(46-82)(47-55)(47-57)(48-50)(48-88)(49-72)(49-93)(50-51)(51-52)(52-53)(53-88)(54-57)(54-62)(55-87)(56-60)(56-65)(58-60)(58-66)(59-64)(59-67)(61-64)(61-77)(62-87)(63-76)(63-78)(65-90)(66-90)(67-91)(68-70)(68-73)(69-71)(69-73)(70-89)(71-89)(74-76)(74-79)(75-83)(75-84)(77-91)(78-92)(79-92)(80-81)(80-85)(81-86)(82-95)(83-96)(84-97)(85-99)(86-100)(87-99)(88-98)(89-98)(90-99)(91-100)(92-100)(93-95)(93-98)(94-96)(94-97)(94-101)(95-102)(96-102)(97-102)(98-102)(99-102)(100-102)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.12 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| MDA-MB-231 | 0.14 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| MCF-10A | 0.42 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| MRC-5 | 0.88 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the compound induces cell death by an apoptotic pathway in a dose-dependent manner, according to annexin V-PE assay.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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