Info
| ID | 95 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"S": 1, "N": 2, "P": 3} |
| Abbreviation | Ru1 |
| SMILES | [S-]C1=NCCS1.c1ccc(P(CCCCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccn2)cc1 |
TUCAN
C48H46N2P3RuS2/(1-54)(2-51)(3-50)(4-53)(5-52)(6-80)(7-84)(8-84)(9-48)(10-69)(11-47)(12-73)(13-49)(14-80)(15-57)(16-59)(17-58)(18-81)(19-62)(20-56)(21-74)(22-65)(23-81)(24-60)(25-61)(26-85)(27-63)(28-67)(29-66)(30-93)(31-93)(32-83)(33-83)(34-64)(35-76)(36-55)(37-82)(38-71)(39-68)(40-85)(41-75)(42-70)(43-77)(44-78)(45-72)(46-79)(47-73)(47-82)(48-49)(48-58)(49-88)(50-73)(50-92)(51-53)(51-54)(52-53)(52-55)(54-86)(55-86)(56-57)(56-88)(57-58)(59-60)(59-61)(60-89)(61-62)(62-63)(63-89)(64-65)(64-90)(65-66)(66-67)(67-68)(68-90)(69-71)(69-74)(70-72)(70-74)(71-87)(72-87)(75-77)(75-91)(76-77)(76-79)(78-79)(78-91)(80-81)(80-84)(81-85)(82-95)(83-93)(83-96)(84-98)(85-99)(86-97)(87-97)(88-98)(89-98)(90-99)(91-99)(92-95)(92-97)(93-101)(94-96)(94-100)(94-101)(95-102)(96-102)(97-102)(98-102)(99-102)(101-102)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.17 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| A549 | 0.23 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| MCF-10A | 0.3 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
| MRC-5 | 0.99 | — | 10.1021/acs.inorgchem.0c01835 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the compound induces cell death by an apoptotic pathway in a dose-dependent manner, according to annexin V-PE assay.»