Info
| ID | 94 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 2, "N": 6} |
| Abbreviation | 9 |
| SMILES | [C-]#[N+]CP(=O)(OCC)OCC.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1cnn(C(n2cccn2)n2cccn2)c1 |
TUCAN
C34H37N7O3P2Ru/(1-65)(2-62)(3-60)(4-49)(5-61)(6-42)(7-41)(8-59)(9-44)(10-45)(11-50)(12-43)(13-47)(14-46)(15-52)(16-48)(17-51)(18-55)(19-66)(20-38)(21-71)(22-71)(23-38)(24-66)(25-67)(26-38)(27-67)(28-54)(29-40)(30-64)(31-53)(32-56)(33-63)(34-57)(35-39)(36-39)(37-39)(38-66)(39-67)(40-60)(40-62)(41-42)(41-44)(42-43)(43-45)(44-68)(45-68)(46-47)(46-50)(47-48)(48-51)(49-59)(49-61)(50-69)(51-69)(52-55)(52-57)(53-63)(53-64)(54-55)(54-70)(56-57)(56-70)(58-76)(59-72)(60-77)(61-73)(62-74)(63-75)(64-78)(65-73)(65-74)(65-75)(66-80)(67-81)(68-82)(69-82)(70-82)(71-76)(71-83)(72-73)(74-77)(75-78)(76-84)(77-84)(78-84)(79-83)(80-83)(80-84)(81-83)(81-84)(82-84)(83-84)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RD | 24 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HCT-116 | 35 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HeLa | 36 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| 518A2 | 38 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MCF-7 | 43 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MRC5pd30 | 51 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»