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Complex #938 — Ru(2) [Ru/5-FU]

2D Structure

Structure
⬇ MOL V3000

Info

ID938
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 4, "O": 1, "P": 2}
AbbreviationRu/5-FU
SMILESO=c1nc([O-])c(F)c[nH]1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

TUCAN

C50H40FN4O2P2Ru/(1-43)(2-46)(3-44)(4-41)(5-48)(6-50)(7-42)(8-45)(9-47)(10-49)(11-51)(12-66)(13-52)(14-53)(15-56)(16-57)(17-54)(18-60)(19-58)(20-55)(21-64)(22-59)(23-78)(24-61)(25-67)(26-68)(27-69)(28-71)(29-65)(30-70)(31-72)(32-73)(33-79)(34-62)(35-63)(36-74)(37-77)(38-76)(39-75)(40-91)(41-43)(41-85)(42-46)(42-85)(43-44)(44-46)(45-48)(45-86)(47-48)(47-50)(49-50)(49-86)(51-52)(51-87)(52-53)(53-56)(54-56)(54-87)(55-57)(55-60)(57-58)(58-88)(59-60)(59-88)(61-64)(61-89)(62-63)(62-66)(63-80)(64-65)(65-69)(66-78)(67-69)(67-89)(68-71)(68-90)(70-71)(70-72)(72-73)(73-90)(74-76)(74-81)(75-76)(75-79)(77-84)(77-91)(78-92)(79-93)(80-81)(80-92)(81-93)(82-84)(82-94)(82-95)(83-91)(83-94)(83-96)(84-97)(85-98)(86-98)(87-98)(88-99)(89-99)(90-99)(92-100)(93-100)(94-100)(98-100)(99-100)

Measurements (37)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
OVCAR-31.2— 10.1038/s41420-023-01759-6 2023
HCT-1161.5— 10.1038/s41598-017-18639-6 2018
A3751.7— 10.1038/s41420-023-01759-6 2023
HSC-31.7— 10.1038/s41598-017-18639-6 2018
PANC-11.8— 10.1038/s41420-023-01759-6 2023
K-5622— 10.1038/s41598-017-18639-6 2018
B16-F102.1— 10.1038/s41598-017-18639-6 2018
SCC-92.3— 10.1038/s41420-023-01759-6 2023
DU-1452.3— 10.1038/s41420-023-01759-6 2023
SCC-92.3— 10.1038/s41598-017-18639-6 2018
SCC-42.4— 10.1038/s41420-023-01759-6 2023
U-87 MG2.5— 10.1038/s41420-023-01759-6 2023
HL602.6— 10.1038/s41598-017-18639-6 2018
MDA-MB-2312.7— 10.1038/s41420-023-01759-6 2023
HepG22.8— 10.1038/s41598-017-18639-6 2018
THP-12.9— 10.1038/s41420-023-01759-6 2023
BJ3.1— 10.1038/s41420-023-01759-6 2023
HepG23.2— 10.1038/s41420-023-01759-6 2023
B16-F103.2— 10.1038/s41420-023-01759-6 2023
4T13.7— 10.1038/s41420-023-01759-6 2023
NCI-H12994— 10.1038/s41420-023-01759-6 2023
HL604.2— 10.1038/s41420-023-01759-6 2023
NB44.3— 10.1038/s41420-023-01759-6 2023
Jurkat4.3— 10.1038/s41420-023-01759-6 2023
K-5624.4— 10.1038/s41420-023-01759-6 2023
HSC-35— 10.1038/s41420-023-01759-6 2023
CAL-275.3— 10.1038/s41420-023-01759-6 2023
KG-1a5.4— 10.1038/s41420-023-01759-6 2023
PBMC5.7— 10.1038/s41598-017-18639-6 2018
MRC-57.1— 10.1038/s41420-023-01759-6 2023
A5497.5— 10.1038/s41420-023-01759-6 2023
MCF-77.6— 10.1038/s41598-017-18639-6 2018
SCC-257.8— 10.1038/s41420-023-01759-6 2023
HCT-1168— 10.1038/s41420-023-01759-6 2023
PBMC8.9— 10.1038/s41420-023-01759-6 2023
MCF-79.2— 10.1038/s41420-023-01759-6 2023
MRC-59.5— 10.1038/s41598-017-18639-6 2018

🧬 Cell Death Types (2)

Apoptosis high
«Initially, we detected that the levels of PARP cleavage (Asp214) (Fig. 1B, C) were increased and the expression of BIRC5 and CDK5 genes (Fig. 2A and Table S3) was reduced in Ru/5-FU-treated HCT116 cel...»
Autophagy high
«Ru/5-FU treatment increased LC3B (Fig. 4A, B, E) and reduced p62/SQSTM1 (Fig. 4C, D, F), indicating the induction of autophagy. Furthermore, transmission electron microscopy (TEM) analysis indicated t...»

Source-assisted 2D generator

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experimental validation surface
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