Info
| ID | 938 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 1, "P": 2} |
| Abbreviation | Ru/5-FU |
| SMILES | O=c1nc([O-])c(F)c[nH]1.c1ccc(-c2ccccn2)nc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C50H40FN4O2P2Ru/(1-43)(2-46)(3-44)(4-41)(5-48)(6-50)(7-42)(8-45)(9-47)(10-49)(11-51)(12-66)(13-52)(14-53)(15-56)(16-57)(17-54)(18-60)(19-58)(20-55)(21-64)(22-59)(23-78)(24-61)(25-67)(26-68)(27-69)(28-71)(29-65)(30-70)(31-72)(32-73)(33-79)(34-62)(35-63)(36-74)(37-77)(38-76)(39-75)(40-91)(41-43)(41-85)(42-46)(42-85)(43-44)(44-46)(45-48)(45-86)(47-48)(47-50)(49-50)(49-86)(51-52)(51-87)(52-53)(53-56)(54-56)(54-87)(55-57)(55-60)(57-58)(58-88)(59-60)(59-88)(61-64)(61-89)(62-63)(62-66)(63-80)(64-65)(65-69)(66-78)(67-69)(67-89)(68-71)(68-90)(70-71)(70-72)(72-73)(73-90)(74-76)(74-81)(75-76)(75-79)(77-84)(77-91)(78-92)(79-93)(80-81)(80-92)(81-93)(82-84)(82-94)(82-95)(83-91)(83-94)(83-96)(84-97)(85-98)(86-98)(87-98)(88-99)(89-99)(90-99)(92-100)(93-100)(94-100)(98-100)(99-100)
Measurements (37)
🧬 Cell Death Types (2)
Apoptosis
high
«Initially, we detected that the levels of PARP cleavage (Asp214) (Fig. 1B, C) were increased and the expression of BIRC5 and CDK5 genes (Fig. 2A and Table S3) was reduced in Ru/5-FU-treated HCT116 cel...»
Autophagy
high
«Ru/5-FU treatment increased LC3B (Fig. 4A, B, E) and reduced p62/SQSTM1 (Fig. 4C, D, F), indicating the induction of autophagy. Furthermore, transmission electron microscopy (TEM) analysis indicated t...»