Info
| ID | 93 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 7, "P": 1} |
| Abbreviation | 8 |
| SMILES | [C-]#[N+]C1CCCCC1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1cnn(C(n2cccn2)n2cccn2)c1 |
TUCAN
C35H36N7PRu/(1-65)(2-58)(3-38)(4-37)(5-63)(6-61)(7-44)(8-41)(9-39)(10-43)(11-46)(12-42)(13-50)(14-45)(15-40)(16-51)(17-49)(18-67)(19-58)(20-55)(21-56)(22-56)(23-55)(24-57)(25-53)(26-62)(27-66)(28-48)(29-52)(30-47)(31-64)(32-54)(33-68)(34-57)(35-59)(36-59)(37-38)(37-41)(38-39)(39-43)(40-42)(40-45)(41-69)(42-46)(43-69)(44-61)(44-63)(45-50)(46-70)(47-62)(47-65)(48-64)(48-66)(49-51)(49-53)(50-70)(51-52)(52-71)(53-54)(54-71)(55-56)(55-58)(56-57)(57-59)(58-67)(59-67)(60-76)(61-73)(62-72)(63-77)(64-74)(65-75)(66-78)(67-76)(68-73)(68-74)(68-75)(69-79)(70-79)(71-79)(72-75)(73-77)(74-78)(76-80)(77-80)(78-80)(79-80)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RD | 6.6 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HCT-116 | 8 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MCF-7 | 10 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| 518A2 | 10 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HeLa | 15 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MRC5pd30 | 20 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»