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Complex #93 — Ru(2) [8]

2D Structure

Structure
⬇ MOL V3000

Info

ID93
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 7, "P": 1}
Abbreviation8
SMILES[C-]#[N+]C1CCCCC1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1cnn(C(n2cccn2)n2cccn2)c1

TUCAN

C35H36N7PRu/(1-65)(2-58)(3-38)(4-37)(5-63)(6-61)(7-44)(8-41)(9-39)(10-43)(11-46)(12-42)(13-50)(14-45)(15-40)(16-51)(17-49)(18-67)(19-58)(20-55)(21-56)(22-56)(23-55)(24-57)(25-53)(26-62)(27-66)(28-48)(29-52)(30-47)(31-64)(32-54)(33-68)(34-57)(35-59)(36-59)(37-38)(37-41)(38-39)(39-43)(40-42)(40-45)(41-69)(42-46)(43-69)(44-61)(44-63)(45-50)(46-70)(47-62)(47-65)(48-64)(48-66)(49-51)(49-53)(50-70)(51-52)(52-71)(53-54)(54-71)(55-56)(55-58)(56-57)(57-59)(58-67)(59-67)(60-76)(61-73)(62-72)(63-77)(64-74)(65-75)(66-78)(67-76)(68-73)(68-74)(68-75)(69-79)(70-79)(71-79)(72-75)(73-77)(74-78)(76-80)(77-80)(78-80)(79-80)

Measurements (6)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
RD6.6 10.1021/acs.jmedchem.2c00722 2022
HCT-1168 10.1021/acs.jmedchem.2c00722 2022
MCF-710 10.1021/acs.jmedchem.2c00722 2022
518A210 10.1021/acs.jmedchem.2c00722 2022
HeLa15 10.1021/acs.jmedchem.2c00722 2022
MRC5pd3020 10.1021/acs.jmedchem.2c00722 2022

🧬 Cell Death Types (1)

Apoptosis high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»