Info
| ID | 92 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 2, "N": 6} |
| Abbreviation | 7 |
| SMILES | COP(OC)OC.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1cnn(C(n2cccn2)n2cccn2)c1 |
TUCAN
C31H34N6O3P2Ru/(1-43)(2-57)(3-53)(4-54)(5-37)(6-35)(7-55)(8-39)(9-38)(10-47)(11-42)(12-36)(13-40)(14-41)(15-51)(16-44)(17-46)(18-60)(19-60)(20-60)(21-61)(22-61)(23-61)(24-50)(25-45)(26-59)(27-56)(28-49)(29-58)(30-48)(31-52)(32-62)(33-62)(34-62)(35-37)(35-63)(36-39)(36-63)(37-38)(38-39)(40-42)(40-64)(41-44)(41-64)(42-47)(43-53)(43-55)(44-47)(45-54)(45-57)(46-50)(46-51)(48-56)(48-58)(49-50)(49-52)(51-65)(52-65)(53-67)(54-70)(55-66)(56-71)(57-68)(58-69)(59-67)(59-68)(59-69)(60-72)(61-73)(62-74)(63-75)(64-75)(65-75)(66-67)(68-70)(69-71)(70-77)(71-77)(72-76)(72-77)(73-76)(73-77)(74-76)(74-77)(75-77)(76-77)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 6 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| RD | 6 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HCT-116 | 6.7 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| 518A2 | 6.8 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HeLa | 10 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MRC5pd30 | 24 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»