Info
| ID | 90 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 1, "N": 5} |
| Abbreviation | 5 |
| SMILES | [Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1cn[nH]c1.c1cnn(C(n2cccn2)n2cccn2)c1 |
TUCAN
C31H29N8PRu/(1-32)(2-31)(3-49)(4-34)(5-37)(6-33)(7-35)(8-56)(9-30)(10-55)(11-57)(12-39)(13-38)(14-41)(15-53)(16-51)(17-46)(18-50)(19-45)(20-52)(21-54)(22-36)(23-42)(24-44)(25-43)(26-47)(27-40)(28-48)(29-62)(30-50)(30-56)(31-49)(31-51)(32-34)(32-58)(33-34)(33-37)(35-37)(35-58)(36-38)(36-59)(38-39)(39-41)(40-43)(40-48)(41-42)(42-59)(43-44)(44-60)(45-53)(45-55)(46-52)(46-54)(47-48)(47-60)(49-63)(50-67)(51-66)(52-65)(53-61)(54-68)(55-64)(56-62)(57-63)(57-64)(57-65)(58-69)(59-69)(60-69)(61-64)(62-67)(63-66)(65-68)(66-70)(67-70)(68-70)(69-70)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| RD | 23 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HCT-116 | 30 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| 518A2 | 31 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MCF-7 | 32 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HeLa | 54 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MRC5pd30 | 63 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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