Info
| ID | 89 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 1, "N": 5} |
| Abbreviation | 4 |
| SMILES | [Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc2[nH]cnc2c1.c1cnn(C(n2cccn2)n2cccn2)c1 |
TUCAN
C35H31N8PRu/(1-37)(2-32)(3-54)(4-34)(5-50)(6-35)(7-62)(8-40)(9-36)(10-38)(11-33)(12-55)(13-56)(14-39)(15-44)(16-45)(17-57)(18-59)(19-51)(20-46)(21-47)(22-58)(23-63)(24-41)(25-42)(26-48)(27-43)(28-49)(29-53)(30-52)(31-67)(32-54)(32-55)(33-45)(33-61)(34-37)(34-64)(35-38)(35-64)(36-37)(36-38)(39-40)(39-42)(40-65)(41-44)(41-65)(42-44)(43-49)(43-66)(45-46)(46-50)(47-56)(47-57)(48-49)(48-52)(50-60)(51-58)(51-59)(52-53)(53-66)(54-69)(55-73)(56-70)(57-68)(58-71)(59-74)(60-61)(60-72)(61-67)(62-67)(62-72)(63-69)(63-70)(63-71)(64-75)(65-75)(66-75)(68-70)(69-73)(71-74)(72-76)(73-76)(74-76)(75-76)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 25 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| RD | 25 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| 518A2 | 35 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HeLa | 36 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MCF-7 | 37 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MRC5pd30 | 57 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»