Info
| ID | 88 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5, "P": 1} |
| Abbreviation | 3 |
| SMILES | Cn1ccnc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1cnn(C(n2cccn2)n2cccn2)c1 |
TUCAN
C32H31N8PRu/(1-52)(2-55)(3-35)(4-38)(5-39)(6-51)(7-34)(8-36)(9-33)(10-41)(11-40)(12-45)(13-37)(14-44)(15-46)(16-48)(17-50)(18-50)(19-50)(20-47)(21-56)(22-58)(23-43)(24-42)(25-32)(26-57)(27-49)(28-60)(29-59)(30-54)(31-53)(32-55)(32-56)(33-34)(33-36)(34-35)(35-61)(36-38)(37-41)(37-45)(38-61)(39-51)(39-52)(40-41)(40-62)(42-47)(42-49)(43-57)(43-58)(44-45)(44-62)(46-47)(46-63)(48-49)(48-63)(50-64)(51-66)(52-70)(53-54)(53-64)(54-69)(55-67)(56-65)(57-68)(58-71)(59-64)(59-69)(60-66)(60-67)(60-68)(61-72)(62-72)(63-72)(65-67)(66-70)(68-71)(69-73)(70-73)(71-73)(72-73)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 25 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| RD | 27 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| 518A2 | 33 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MCF-7 | 38 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MRC5pd30 | 84 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HeLa | 91 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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