Info
| ID | 86 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 2, "N": 6} |
| Abbreviation | 1 |
| SMILES | [Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1cnn(C(n2cccn2)n2cccn2)c1 |
TUCAN
C46H40N6P2Ru/(1-43)(2-74)(3-75)(4-42)(5-41)(6-44)(7-47)(8-46)(9-45)(10-49)(11-48)(12-51)(13-53)(14-50)(15-52)(16-58)(17-76)(18-54)(19-55)(20-57)(21-59)(22-60)(23-61)(24-64)(25-62)(26-67)(27-68)(28-63)(29-73)(30-56)(31-79)(32-69)(33-65)(34-77)(35-78)(36-66)(37-80)(38-70)(39-71)(40-72)(41-43)(41-81)(42-74)(42-75)(43-47)(44-45)(44-47)(45-81)(46-49)(46-51)(48-50)(48-51)(49-82)(50-82)(52-53)(52-83)(53-55)(54-55)(54-58)(56-76)(56-77)(57-59)(57-64)(58-83)(59-84)(60-62)(60-84)(61-63)(61-85)(62-64)(63-66)(65-66)(65-67)(67-85)(68-70)(68-86)(69-78)(69-79)(70-71)(71-72)(72-73)(73-86)(74-91)(75-88)(76-87)(77-89)(78-90)(79-92)(80-88)(80-89)(80-90)(81-93)(82-93)(83-93)(84-94)(85-94)(86-94)(87-89)(88-91)(90-92)(91-95)(92-95)(93-95)(94-95)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 1.5 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| RD | 2.2 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MCF-7 | 2.4 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| 518A2 | 2.6 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| HeLa | 4 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
| MRC5pd30 | 5.8 | — | 10.1021/acs.jmedchem.2c00722 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«All tested complexes effectively induced apoptosis in HCT116 cells (Annexin-V-positive/PI-negative cells), whereas the percentage of cells undergoing necrosis was negligible (0.2–0.3%).»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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