Info
| ID | 853 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru2 |
| SMILES | Oc1cccc2ccc(C3=NC4c5cccnc5-c5ncccc5C4N3)nc12.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C46H31N9ORu/(1-60)(2-45)(3-51)(4-75)(5-34)(6-61)(7-33)(8-62)(9-32)(10-36)(11-38)(12-49)(13-50)(14-64)(15-35)(16-39)(17-52)(18-41)(19-40)(20-47)(21-37)(22-42)(23-43)(24-63)(25-74)(26-48)(27-65)(28-44)(29-46)(30-80)(31-87)(32-34)(32-53)(33-37)(33-53)(34-60)(35-36)(35-54)(36-61)(37-54)(38-42)(38-62)(39-40)(39-59)(40-63)(41-52)(41-55)(42-56)(43-44)(43-56)(44-58)(45-49)(45-57)(46-47)(46-58)(47-64)(48-51)(48-72)(49-50)(50-77)(51-57)(52-65)(53-66)(54-67)(55-71)(55-74)(56-70)(57-69)(58-73)(59-68)(59-75)(60-81)(61-82)(62-84)(63-78)(64-86)(65-85)(66-67)(66-81)(67-82)(68-71)(68-78)(69-77)(69-79)(70-73)(70-84)(71-85)(72-76)(72-79)(73-86)(74-75)(74-83)(75-80)(76-80)(76-83)(77-87)(81-88)(82-88)(83-88)(84-88)(85-88)(86-88)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 22 | 2.8 | 10.1039/d2dt01765b | 2022 |
| A549 | 22 | 0.8 | 10.1039/d2dt01765b | 2022 |
| A549cisR | 35 | 2.4 | 10.1039/d2dt01765b | 2022 |
| HeLa | 45 | 3.7 | 10.1039/d2dt01765b | 2022 |
| MCF-7 | 50 | 2.1 | 10.1039/d2dt01765b | 2022 |
| LO2 | 56 | 6.9 | 10.1039/d2dt01765b | 2022 |
| HepG2 | — | 3.9 | 10.1039/d2dt01765b | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«The mechanistic studies indicated that Ru1 and Ru2 could induce apoptosis through the combination of JMJD inhibitory and PDT activities, as evidenced by depolarization of mitochondrial membrane potent...»