Info
| ID | 835 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | K1 |
| SMILES | [Cl-].c1ccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)cc1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C33H23N5Ru/(1-24)(2-41)(3-25)(4-32)(5-50)(6-26)(7-47)(8-33)(9-28)(10-29)(11-35)(12-40)(13-27)(14-38)(15-34)(16-36)(17-31)(18-49)(19-39)(20-30)(21-42)(22-37)(23-48)(24-27)(24-28)(25-36)(25-47)(26-35)(26-43)(27-33)(28-46)(29-31)(29-50)(30-31)(30-54)(32-45)(32-53)(33-38)(34-37)(34-48)(35-44)(36-43)(37-44)(38-46)(39-41)(39-49)(40-41)(40-56)(42-45)(42-55)(43-51)(44-52)(45-46)(47-58)(48-59)(49-60)(50-57)(51-52)(51-58)(52-59)(53-56)(53-61)(54-55)(54-57)(55-61)(56-60)(58-62)(59-62)(60-62)(61-62)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 7.8 | — | 10.5937/erhs2201006z | 2022 |
| HCT-116 | 19 | — | 10.5937/erhs2201006z | 2022 |
| A375 | 38 | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| MCF-7 | 59 | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| A549 | 73 | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| HeLa | 96 | — | 10.1021/acs.inorgchem.4c00650 | 2024 |
| HCT-116 | 1.1e+02 | — | 10.5937/erhs2201006z | 2022 |
| HK-2 | 1.2e+02 | — | 10.1016/j.biomaterials.2017.03... | 2017 |
| HepG2 | 1.4e+02 | — | 10.1016/j.biomaterials.2017.03... | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cell death mechanistic study revealed that Ru3 induced ROS-mediated apoptosis in HeLa cells via mitochondrial depolarization under white or green light exposure.»