Info
| ID | 806 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6, "S": 1} |
| Abbreviation | 6c |
| SMILES | CC(C)c1ccc2c(c1)CCC1[C@](C)(C(=O)N3CCN(C(=S)[S-])CC3)CCC[C@]21C.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C45H51N6ORuS2/(1-88)(2-56)(3-88)(4-74)(5-73)(6-57)(7-73)(8-58)(9-59)(10-87)(11-64)(12-65)(13-83)(14-84)(15-60)(16-90)(17-62)(18-52)(19-52)(20-52)(21-61)(22-55)(23-55)(24-90)(25-87)(26-89)(27-55)(28-80)(29-71)(30-53)(31-53)(32-53)(33-79)(34-74)(35-75)(36-54)(37-85)(38-67)(39-68)(40-72)(41-71)(42-54)(43-75)(44-89)(45-54)(46-66)(47-70)(48-69)(49-86)(50-63)(51-72)(52-79)(53-79)(54-81)(55-82)(56-57)(56-58)(57-83)(58-91)(59-60)(59-64)(60-92)(61-62)(61-78)(62-76)(63-76)(63-77)(64-84)(65-68)(65-85)(66-70)(66-86)(67-68)(67-93)(69-70)(69-94)(71-72)(71-80)(72-77)(73-74)(73-81)(74-75)(75-82)(76-79)(77-78)(78-81)(80-81)(80-82)(82-95)(83-99)(84-100)(85-101)(86-102)(87-88)(87-97)(88-98)(89-90)(89-97)(90-98)(91-92)(91-99)(92-100)(93-94)(93-101)(94-102)(95-97)(95-103)(96-98)(96-104)(96-105)(99-106)(100-106)(101-106)(102-106)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 1 | — | 10.3390/molecules26051453 | 2021 |
| MDA-MB-231 | 1.3 | — | 10.3390/molecules26051453 | 2021 |
| MGC-803 | 1.6 | — | 10.3390/molecules26051453 | 2021 |
| A549cisR | 1.8 | — | 10.3390/molecules26051453 | 2021 |
| HepG2 | 2.2 | — | 10.3390/molecules26051453 | 2021 |
| MCF-7 | 3.6 | — | 10.3390/molecules26051453 | 2021 |
| CNE-2 | 4.2 | — | 10.3390/molecules26051453 | 2021 |
| A549 | 5.5 | — | 10.3390/molecules26051453 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Acridine orange (AO) staining assay results (Figure 6) showed that the morphology of 6a- and 6c-treated T-24 cells exhibited clear changes and that cell nuclei were stained as yellow/orange, indicatin...»