Info
| ID | 804 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6, "S": 1} |
| Abbreviation | 6a |
| SMILES | CC(C)c1ccc2c(c1)CCC1[C@](C)(C(=O)N3CCN(C(=S)[S-])CC3)CCC[C@]21C.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C49H51N6ORuS2/(1-93)(2-58)(3-93)(4-91)(5-75)(6-59)(7-56)(8-91)(9-61)(10-57)(11-87)(12-67)(13-62)(14-94)(15-65)(16-52)(17-52)(18-52)(19-64)(20-54)(21-54)(22-94)(23-92)(24-92)(25-54)(26-84)(27-71)(28-53)(29-53)(30-53)(31-83)(32-60)(33-63)(34-55)(35-73)(36-74)(37-88)(38-55)(39-70)(40-71)(41-72)(42-68)(43-69)(44-55)(45-74)(46-75)(47-73)(48-89)(49-90)(50-72)(51-66)(52-83)(53-83)(54-85)(55-86)(56-61)(56-87)(57-62)(57-88)(58-59)(58-76)(59-77)(60-70)(60-81)(61-76)(62-77)(63-67)(63-81)(64-65)(64-80)(65-78)(66-78)(66-79)(67-89)(68-69)(68-82)(69-90)(70-82)(71-72)(71-84)(72-79)(73-74)(73-86)(74-75)(75-85)(76-95)(77-96)(78-83)(79-80)(80-86)(81-97)(82-98)(84-85)(84-86)(85-99)(87-103)(88-104)(89-105)(90-106)(91-93)(91-101)(92-94)(92-101)(93-102)(94-102)(95-96)(95-103)(96-104)(97-98)(97-105)(98-106)(99-101)(99-107)(100-102)(100-108)(100-109)(103-110)(104-110)(105-110)(106-110)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MGC-803 | 1.2 | — | 10.3390/molecules26051453 | 2021 |
| T24 | 1.2 | — | 10.3390/molecules26051453 | 2021 |
| A549cisR | 1.3 | — | 10.3390/molecules26051453 | 2021 |
| HepG2 | 2 | — | 10.3390/molecules26051453 | 2021 |
| MCF-7 | 2.1 | — | 10.3390/molecules26051453 | 2021 |
| CNE-2 | 3.2 | — | 10.3390/molecules26051453 | 2021 |
| MDA-MB-231 | 3.4 | — | 10.3390/molecules26051453 | 2021 |
| A549 | 5.2 | — | 10.3390/molecules26051453 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Acridine orange (AO) staining assay results (Figure 6) showed that the morphology of 6a- and 6c-treated T-24 cells exhibited clear changes and that cell nuclei were stained as yellow/orange, indicatin...»