Info
| ID | 803 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "P": 4} |
| Abbreviation | Hmxbato |
| SMILES | COc1ccc(C(=O)[O-])cc1.c1ccc(P(CP(c2ccccc2)c2ccccc2)c2ccccc2)cc1.c1ccc(P(CP(c2ccccc2)c2ccccc2)c2ccccc2)cc1 |
TUCAN
C58H51O3P4Ru/(1-54)(2-55)(3-108)(4-52)(5-108)(6-53)(7-58)(8-56)(9-61)(10-57)(11-64)(12-72)(13-59)(14-60)(15-65)(16-66)(17-62)(18-67)(19-69)(20-63)(21-78)(22-73)(23-109)(24-86)(25-74)(26-75)(27-68)(28-70)(29-77)(30-71)(31-76)(32-80)(33-84)(34-92)(35-83)(36-79)(37-81)(38-87)(39-82)(40-95)(41-85)(42-90)(43-93)(44-89)(45-91)(46-109)(47-94)(48-97)(49-97)(50-97)(51-88)(52-54)(52-55)(53-55)(53-58)(54-100)(56-60)(56-61)(57-61)(57-65)(58-100)(59-64)(59-66)(60-101)(62-64)(62-67)(63-69)(63-72)(65-101)(66-102)(67-102)(68-72)(68-73)(69-103)(70-75)(70-78)(71-77)(71-78)(73-103)(74-86)(74-96)(75-104)(76-79)(76-84)(77-104)(79-105)(80-81)(80-84)(81-105)(82-83)(82-106)(83-92)(85-87)(85-106)(86-98)(87-92)(88-91)(88-98)(89-90)(89-107)(90-95)(91-96)(93-94)(93-95)(94-107)(96-99)(97-112)(98-112)(99-110)(99-111)(100-113)(101-113)(102-114)(103-114)(104-115)(105-115)(106-116)(107-116)(108-113)(108-114)(109-115)(109-116)(112-117)(113-117)(114-117)(115-117)(116-117)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 3.8 | — | 10.1038/s41598-020-72420-w | 2020 |
| BEAS-2B | 40 | — | 10.1038/s41598-020-72420-w | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Treatment of A549 cells with hmxbato at concentrations of 3.8 µM and 19 µM induced apoptosis (early and late) in 51.46% and 42.78% of cells, respectively. ... Hmxbato increased the caspase-9 activity ...»