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Complex #80 — Ru(2) [Ru7]

2D Structure

Structure
⬇ MOL V3000

Info

ID80
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 8}
AbbreviationRu7
SMILES[c-]1ccccc1-c1ccccn1.c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34.c1ccc(-c2ccccn2)nc1

TUCAN

C42H27N8Ru/(1-62)(2-47)(3-37)(4-34)(5-40)(6-41)(7-49)(8-42)(9-58)(10-59)(11-36)(12-32)(13-31)(14-45)(15-44)(16-57)(17-29)(18-30)(19-38)(20-35)(21-48)(22-43)(23-33)(24-61)(25-39)(26-60)(27-46)(28-34)(28-51)(29-30)(29-42)(30-50)(31-37)(31-59)(32-47)(32-53)(33-44)(33-61)(34-35)(35-38)(36-37)(36-65)(38-41)(39-40)(39-46)(40-60)(41-51)(42-54)(43-47)(43-52)(44-45)(45-66)(46-68)(48-49)(48-52)(49-54)(50-55)(50-63)(51-68)(52-56)(53-56)(53-67)(54-55)(55-56)(57-58)(57-76)(58-70)(59-74)(60-75)(61-77)(62-64)(62-76)(63-67)(63-73)(64-69)(64-70)(65-66)(65-74)(66-77)(67-71)(68-75)(69-72)(69-73)(71-72)(73-78)(74-78)(75-78)(76-78)(77-78)

Measurements (9)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
A549cisR2.2 10.1002/anie.202006089 2020
HeLa2.3 10.1002/anie.202006089 2020
SGC-79012.5 10.1002/anie.202006089 2020
SGC-7901/DDP2.8 10.1002/anie.202006089 2020
A5493 10.1002/anie.202006089 2020
HepG26.7 10.1002/anie.202006089 2020
BEL-74029.5 10.1002/anie.202006089 2020
BEAS-2B18 10.1002/anie.202006089 2020
LO219 10.1002/anie.202006089 2020

🧬 Cell Death Types (1)

Necroptosis high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»