Info
| ID | 80 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru7 |
| SMILES | [c-]1ccccc1-c1ccccn1.c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34.c1ccc(-c2ccccn2)nc1 |
TUCAN
C42H27N8Ru/(1-62)(2-47)(3-37)(4-34)(5-40)(6-41)(7-49)(8-42)(9-58)(10-59)(11-36)(12-32)(13-31)(14-45)(15-44)(16-57)(17-29)(18-30)(19-38)(20-35)(21-48)(22-43)(23-33)(24-61)(25-39)(26-60)(27-46)(28-34)(28-51)(29-30)(29-42)(30-50)(31-37)(31-59)(32-47)(32-53)(33-44)(33-61)(34-35)(35-38)(36-37)(36-65)(38-41)(39-40)(39-46)(40-60)(41-51)(42-54)(43-47)(43-52)(44-45)(45-66)(46-68)(48-49)(48-52)(49-54)(50-55)(50-63)(51-68)(52-56)(53-56)(53-67)(54-55)(55-56)(57-58)(57-76)(58-70)(59-74)(60-75)(61-77)(62-64)(62-76)(63-67)(63-73)(64-69)(64-70)(65-66)(65-74)(66-77)(67-71)(68-75)(69-72)(69-73)(71-72)(73-78)(74-78)(75-78)(76-78)(77-78)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549cisR | 2.2 | — | 10.1002/anie.202006089 | 2020 |
| HeLa | 2.3 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901 | 2.5 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901/DDP | 2.8 | — | 10.1002/anie.202006089 | 2020 |
| A549 | 3 | — | 10.1002/anie.202006089 | 2020 |
| HepG2 | 6.7 | — | 10.1002/anie.202006089 | 2020 |
| BEL-7402 | 9.5 | — | 10.1002/anie.202006089 | 2020 |
| BEAS-2B | 18 | — | 10.1002/anie.202006089 | 2020 |
| LO2 | 19 | — | 10.1002/anie.202006089 | 2020 |
🧬 Cell Death Types (1)
Necroptosis
high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»