Info
| ID | 79 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru6 |
| SMILES | c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C69H43N9Ru/(1-46)(2-98)(3-51)(4-45)(5-49)(6-52)(7-44)(8-69)(9-48)(10-57)(11-47)(12-50)(13-55)(14-70)(15-73)(16-53)(17-76)(18-56)(19-59)(20-58)(21-99)(22-60)(23-62)(24-61)(25-100)(26-54)(27-68)(28-104)(29-79)(30-74)(31-102)(32-101)(33-67)(34-65)(35-78)(36-66)(37-71)(38-72)(39-75)(40-103)(41-77)(42-63)(43-64)(44-46)(44-47)(45-80)(45-98)(46-87)(47-48)(48-49)(49-87)(50-55)(50-57)(51-52)(51-81)(52-86)(53-76)(53-82)(54-85)(54-99)(55-56)(56-58)(57-89)(58-89)(59-60)(59-68)(60-90)(61-62)(61-90)(62-68)(63-77)(63-92)(64-74)(64-91)(65-66)(65-94)(66-78)(67-93)(67-100)(69-70)(69-88)(70-96)(71-95)(71-101)(72-75)(72-94)(73-76)(73-92)(74-79)(75-78)(77-97)(79-97)(80-81)(80-87)(81-105)(82-83)(82-109)(83-84)(83-92)(84-91)(84-97)(85-86)(85-89)(86-107)(88-93)(88-108)(90-93)(91-110)(94-95)(95-96)(96-111)(98-116)(99-118)(100-119)(101-120)(102-104)(102-113)(103-106)(103-121)(104-121)(105-107)(105-116)(106-112)(106-113)(107-118)(108-111)(108-119)(109-110)(109-115)(110-117)(111-120)(112-114)(112-117)(114-115)(116-122)(117-122)(118-122)(119-122)(120-122)(121-122)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 14 | — | 10.1002/anie.202006089 | 2020 |
| BEL-7402 | 19 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901/DDP | 20 | — | 10.1002/anie.202006089 | 2020 |
| HeLa | 21 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901 | 27 | — | 10.1002/anie.202006089 | 2020 |
| A549cisR | 28 | — | 10.1002/anie.202006089 | 2020 |
| A549 | 37 | — | 10.1002/anie.202006089 | 2020 |
| LO2 | 42 | — | 10.1002/anie.202006089 | 2020 |
| BEAS-2B | 53 | — | 10.1002/anie.202006089 | 2020 |
🧬 Cell Death Types (1)
Necroptosis
high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»