Info
| ID | 784 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | Ru1 |
| SMILES | COc1cc2c(cc1OC)C(c1[c-]cccc1)=NCC2.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C37H32N5O2Ru/(1-56)(2-38)(3-43)(4-57)(5-36)(6-35)(7-58)(8-37)(9-60)(10-60)(11-52)(12-52)(13-47)(14-39)(15-50)(16-67)(17-67)(18-34)(19-41)(20-42)(21-67)(22-40)(23-49)(24-46)(25-44)(26-66)(27-51)(28-59)(29-45)(30-48)(31-66)(32-66)(33-50)(33-54)(34-41)(34-54)(35-38)(35-56)(36-38)(36-61)(37-43)(37-57)(39-43)(39-62)(40-53)(40-69)(41-42)(42-50)(44-46)(44-47)(45-48)(45-49)(46-63)(47-58)(48-64)(49-59)(51-55)(51-68)(52-55)(52-60)(53-55)(53-65)(54-65)(56-70)(57-71)(58-73)(59-74)(60-72)(61-62)(61-70)(62-71)(63-64)(63-73)(64-74)(65-72)(66-75)(67-76)(68-69)(68-75)(69-76)(70-77)(71-77)(72-77)(73-77)(74-77)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| Hs578T | 1.1 | 0.5 | 10.1039/d4md00600c | 2024 |
| MCF-10A | 1.2 | 0.4 | 10.1039/d4md00600c | 2024 |
| A375 | 1.4 | 0.6 | 10.1039/d4md00600c | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The data reported in Fig. 6 showed that: a) 1 can promote the apoptotic death on both cell lines; ... To clarify the mechanism of cell apoptosis induced by 1, the activities of caspase-9 and caspase-3...»