Info
| ID | 781 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru1 |
| SMILES | O=S1(=O)CCN(c2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)CC1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C43H35N9O2RuS/(1-59)(2-60)(3-36)(4-39)(5-61)(6-51)(7-40)(8-64)(9-77)(10-42)(11-41)(12-50)(13-63)(14-37)(15-55)(16-77)(17-49)(18-65)(19-78)(20-65)(21-78)(22-66)(23-44)(24-47)(25-66)(26-54)(27-52)(28-38)(29-43)(30-46)(31-62)(32-45)(33-48)(34-53)(35-80)(36-40)(36-59)(37-42)(37-60)(38-50)(38-61)(39-40)(39-67)(41-42)(41-68)(43-46)(43-70)(44-47)(44-63)(45-48)(45-70)(46-58)(47-56)(48-58)(49-50)(49-71)(51-55)(51-57)(52-54)(52-72)(53-54)(53-62)(55-64)(56-74)(56-75)(57-69)(57-73)(58-76)(59-82)(60-83)(61-85)(62-86)(63-87)(64-79)(65-77)(65-81)(66-78)(66-81)(67-68)(67-82)(68-83)(69-75)(69-80)(70-81)(71-72)(71-85)(72-86)(73-74)(73-79)(74-87)(75-84)(76-80)(76-84)(77-90)(78-90)(82-91)(83-91)(84-91)(85-91)(86-91)(87-91)(88-90)(89-90)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A375 | 63 | 12 | 10.1002/adhm.202403563 | 2024 |
🧬 Cell Death Types (2)
Apoptosis
medium
«The released Ru(II) complexes within cells exert multiple antitumor mechanisms, such as ... apoptosis and ferroptosis induction.»
Ferroptosis
medium
«The released Ru(II) complexes within cells exert multiple antitumor mechanisms, such as ... apoptosis and ferroptosis induction.»