Info
| ID | 78 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru5 |
| SMILES | Cc1ccnc2c1ccc1c(C)ccnc12.Cc1ccnc2c1ccc1c(C)ccnc12.c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34 |
TUCAN
C49H35N9Ru/(1-48)(2-70)(3-41)(4-42)(5-36)(6-71)(7-49)(8-43)(9-36)(10-72)(11-36)(12-73)(13-74)(14-52)(15-75)(16-37)(17-46)(18-37)(19-47)(20-76)(21-37)(22-38)(23-38)(24-44)(25-45)(26-40)(27-53)(28-50)(29-54)(30-51)(31-38)(32-39)(33-39)(34-55)(35-39)(36-56)(37-61)(38-66)(39-67)(40-44)(40-57)(41-42)(41-59)(42-62)(43-47)(43-63)(44-45)(45-65)(46-53)(46-64)(47-69)(48-56)(48-72)(49-61)(49-74)(50-51)(50-57)(51-68)(52-66)(52-75)(53-54)(54-68)(55-67)(55-76)(56-59)(57-60)(58-60)(58-64)(58-68)(59-78)(60-65)(61-62)(62-79)(63-66)(63-82)(64-77)(65-81)(67-69)(69-83)(70-71)(70-85)(71-90)(72-89)(73-80)(73-90)(74-91)(75-92)(76-93)(77-81)(77-88)(78-79)(78-89)(79-91)(80-84)(80-85)(81-86)(82-83)(82-92)(83-93)(84-87)(84-88)(86-87)(88-94)(89-94)(90-94)(91-94)(92-94)(93-94)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901/DDP | 45 | — | 10.1002/anie.202006089 | 2020 |
| A549 | 56 | — | 10.1002/anie.202006089 | 2020 |
| HeLa | 58 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901 | 71 | — | 10.1002/anie.202006089 | 2020 |
| HepG2 | 89 | — | 10.1002/anie.202006089 | 2020 |
| A549cisR | 1.3e+02 | — | 10.1002/anie.202006089 | 2020 |
| BEL-7402 | 1.3e+02 | — | 10.1002/anie.202006089 | 2020 |
| LO2 | 1.6e+02 | — | 10.1002/anie.202006089 | 2020 |
| BEAS-2B | 1.6e+02 | — | 10.1002/anie.202006089 | 2020 |
🧬 Cell Death Types (1)
Necroptosis
high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»