Info
| ID | 77 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru4 |
| SMILES | c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C45H27N9Ru/(1-35)(2-33)(3-46)(4-39)(5-47)(6-34)(7-29)(8-58)(9-30)(10-28)(11-59)(12-37)(13-31)(14-32)(15-42)(16-41)(17-40)(18-63)(19-36)(20-38)(21-44)(22-61)(23-64)(24-60)(25-43)(26-62)(27-45)(28-29)(28-58)(29-48)(30-37)(30-49)(31-44)(31-48)(32-35)(32-40)(33-34)(33-51)(34-50)(35-50)(36-42)(36-53)(37-59)(38-43)(38-56)(39-46)(39-55)(40-57)(41-45)(41-49)(42-61)(43-62)(44-53)(45-56)(46-47)(47-51)(48-65)(49-66)(50-54)(51-52)(52-54)(52-55)(53-67)(54-57)(55-70)(56-68)(57-71)(58-76)(59-77)(60-69)(60-78)(61-79)(62-80)(63-64)(63-73)(64-78)(65-67)(65-76)(66-68)(66-77)(67-79)(68-80)(69-72)(69-73)(70-71)(70-81)(71-74)(72-75)(72-81)(74-75)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 65 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901 | 71 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901/DDP | 81 | — | 10.1002/anie.202006089 | 2020 |
| A549cisR | 1.6e+02 | — | 10.1002/anie.202006089 | 2020 |
| BEAS-2B | 1.6e+02 | — | 10.1002/anie.202006089 | 2020 |
| HeLa | 1.6e+02 | — | 10.1002/anie.202006089 | 2020 |
| LO2 | 1.9e+02 | — | 10.1002/anie.202006089 | 2020 |
| HepG2 | — | — | 10.1002/anie.202006089 | 2020 |
| BEL-7402 | — | — | 10.1002/anie.202006089 | 2020 |
🧬 Cell Death Types (1)
Necroptosis
high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»