Info
| ID | 769 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru-LipM |
| SMILES | CCCCCCCCCCCCOc1cc2nc3c4cccnc4c4ncccc4c3nc2cc1OCCCCCCCCCCCC.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C66H74N8O2Ru/(1-92)(2-100)(3-104)(4-103)(5-102)(6-75)(7-75)(8-121)(9-101)(10-77)(11-99)(12-105)(13-122)(14-81)(15-123)(16-82)(17-99)(18-107)(19-84)(20-105)(21-90)(22-75)(23-102)(24-103)(25-104)(26-100)(27-101)(28-93)(29-109)(30-76)(31-97)(32-108)(33-95)(34-96)(35-112)(36-113)(37-86)(38-138)(39-111)(40-112)(41-138)(42-114)(43-113)(44-95)(45-96)(46-97)(47-108)(48-109)(49-76)(50-76)(51-106)(52-79)(53-78)(54-107)(55-88)(56-85)(57-137)(58-106)(59-80)(60-83)(61-114)(62-110)(63-98)(64-89)(65-91)(66-137)(67-124)(68-125)(69-87)(70-98)(71-94)(72-126)(73-110)(74-111)(75-102)(76-109)(77-81)(77-115)(78-80)(78-115)(79-82)(79-116)(80-116)(81-121)(82-122)(83-89)(83-118)(84-91)(84-123)(85-88)(85-124)(86-132)(86-140)(87-133)(87-139)(88-117)(89-119)(90-94)(90-126)(91-118)(92-93)(92-125)(93-120)(94-119)(95-96)(95-113)(96-97)(97-108)(98-99)(98-106)(99-107)(100-101)(100-104)(101-105)(102-103)(103-104)(105-106)(107-137)(108-109)(110-111)(110-114)(111-112)(112-113)(114-138)(115-127)(116-128)(117-130)(117-134)(118-129)(119-135)(120-131)(120-136)(121-143)(122-144)(123-145)(124-142)(125-148)(126-146)(127-128)(127-143)(128-144)(129-135)(129-145)(130-136)(130-141)(131-134)(131-148)(132-133)(132-147)(133-141)(134-142)(135-146)(136-147)(137-149)(138-150)(139-140)(139-149)(140-150)(143-151)(144-151)(145-151)(146-151)(147-151)(148-151)(149-151)(150-151)
Measurements (16)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 35 | 2.2 | 10.1002/advs.202411629 | 2024 |
| MDA-MB-231 | 35 | 0.09 | 10.1002/advs.202411629 | 2024 |
| A549 | 38 | 2.5 | 10.1002/advs.202411629 | 2024 |
| A549 | 38 | 0.22 | 10.1002/advs.202411629 | 2024 |
| U14 | 39 | 1.4 | 10.1002/advs.202411629 | 2024 |
| U14 | 39 | 0.05 | 10.1002/advs.202411629 | 2024 |
| HeLa | — | 2.3 | 10.1002/advs.202411629 | 2024 |
| LLC | — | 2 | 10.1002/advs.202411629 | 2024 |
| 4T1 | — | 2.4 | 10.1002/advs.202411629 | 2024 |
| MCF-10A | — | 6 | 10.1002/advs.202411629 | 2024 |
| HLF | — | 5.2 | 10.1002/advs.202411629 | 2024 |
| HeLa | — | 0.08 | 10.1002/advs.202411629 | 2024 |
| LLC | — | 0.15 | 10.1002/advs.202411629 | 2024 |
| 4T1 | — | 0.12 | 10.1002/advs.202411629 | 2024 |
| MCF-10A | — | 0.43 | 10.1002/advs.202411629 | 2024 |
| HLF | — | 0.25 | 10.1002/advs.202411629 | 2024 |
🧬 Cell Death Types (4)
Apoptosis
medium
«the apoptotic inhibitor z‐VAD‐fmk also increases the cell survival rate, as evidenced by the downregulation of anti‐apoptotic protein B‐cell lymphoma‐2 (Bcl‐2) and upregulation of proapoptotic protein...»
Autophagy
high
«Upon Ru‐LipM treatment, an increase in the levels of LC3‐II, p62, ATG5 and mTOR is detected. Additionally, NCOA4 is also found to be upregulated while ferritin remained unchanged. These findings demon...»
Ferroptosis
high
«the depletion of the anti‐peroxidative guardian GPX4 and the upregulation of the fatty acid‐associated ferroptosis promoter ACSL4 are observed in Ru‐LipM‐treated cells, providing further evidence for ...»
Immunogenic Cell Death
high
«Flow cytometric measurements show that the intracellular fluorescence from etco‐CRT and HMGB1 in Ru‐LipM‐treated cells is increased and decreased in a time‐dependent manner, respectively. Simultaneous...»