Info
| ID | 76 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru3 |
| SMILES | Cc1ccnc(-c2cc(C)ccn2)c1.Cc1ccnc(-c2cc(C)ccn2)c1.c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34 |
TUCAN
C45H35N9Ru/(1-67)(2-66)(3-42)(4-68)(5-36)(6-44)(7-36)(8-70)(9-43)(10-36)(11-52)(12-37)(13-69)(14-37)(15-50)(16-37)(17-49)(18-71)(19-38)(20-38)(21-38)(22-48)(23-46)(24-41)(25-51)(26-47)(27-40)(28-45)(29-53)(30-39)(31-39)(32-55)(33-39)(34-54)(35-72)(36-60)(37-61)(38-63)(39-65)(40-51)(40-58)(41-48)(41-59)(42-60)(42-67)(43-60)(43-73)(44-63)(44-69)(45-47)(45-58)(46-48)(46-62)(47-59)(49-61)(49-71)(50-61)(50-74)(51-52)(52-64)(53-63)(53-75)(54-65)(54-76)(55-65)(55-72)(56-57)(56-58)(56-64)(57-59)(57-62)(62-78)(64-79)(66-68)(66-81)(67-84)(68-85)(69-86)(70-77)(70-85)(71-87)(72-89)(73-74)(73-84)(74-87)(75-76)(75-86)(76-89)(77-80)(77-81)(78-79)(78-82)(79-88)(80-83)(80-88)(82-83)(84-90)(85-90)(86-90)(87-90)(88-90)(89-90)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 1e+02 | — | 10.1002/anie.202006089 | 2020 |
| A549 | 1.2e+02 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901/DDP | 1.2e+02 | — | 10.1002/anie.202006089 | 2020 |
| HepG2 | 1.2e+02 | — | 10.1002/anie.202006089 | 2020 |
| HeLa | 1.2e+02 | — | 10.1002/anie.202006089 | 2020 |
| BEAS-2B | 1.7e+02 | — | 10.1002/anie.202006089 | 2020 |
| A549cisR | 1.7e+02 | — | 10.1002/anie.202006089 | 2020 |
| LO2 | — | — | 10.1002/anie.202006089 | 2020 |
| BEL-7402 | — | — | 10.1002/anie.202006089 | 2020 |
🧬 Cell Death Types (1)
Necroptosis
high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»