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Complex #75 — Ru(2) [Ru2]

2D Structure

Structure
⬇ MOL V3000

Info

ID75
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 6}
AbbreviationRu2
SMILESc1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34.c1ccc(Nc2ccccn2)nc1.c1ccc(Nc2ccccn2)nc1

TUCAN

C41H29N11Ru/(1-44)(2-61)(3-30)(4-45)(5-36)(6-32)(7-56)(8-31)(9-34)(10-33)(11-40)(12-42)(13-35)(14-62)(15-41)(16-58)(17-57)(18-43)(19-59)(20-49)(21-37)(22-38)(23-48)(24-47)(25-46)(26-60)(27-39)(28-72)(29-73)(30-31)(30-56)(31-32)(32-66)(33-34)(33-41)(34-67)(35-39)(35-45)(36-38)(36-52)(37-38)(37-50)(39-54)(40-42)(40-43)(41-57)(42-68)(43-59)(44-49)(44-52)(45-55)(46-47)(46-48)(47-69)(48-60)(49-54)(50-51)(50-63)(51-52)(51-53)(53-54)(53-55)(55-65)(56-76)(57-77)(58-64)(58-81)(59-79)(60-80)(61-62)(61-71)(62-81)(63-65)(63-78)(64-70)(64-71)(65-74)(66-72)(66-76)(67-72)(67-77)(68-73)(68-79)(69-73)(69-80)(70-75)(70-78)(74-75)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)

Measurements (9)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
SGC-7901/DDP53 10.1002/anie.202006089 2020
A54964 10.1002/anie.202006089 2020
SGC-790170 10.1002/anie.202006089 2020
HeLa81 10.1002/anie.202006089 2020
A549cisR82 10.1002/anie.202006089 2020
HepG21.1e+02 10.1002/anie.202006089 2020
BEAS-2B1.4e+02 10.1002/anie.202006089 2020
BEL-74021.9e+02 10.1002/anie.202006089 2020
LO21.9e+02 10.1002/anie.202006089 2020

🧬 Cell Death Types (1)

Necroptosis high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»