Info
| ID | 75 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru2 |
| SMILES | c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34.c1ccc(Nc2ccccn2)nc1.c1ccc(Nc2ccccn2)nc1 |
TUCAN
C41H29N11Ru/(1-44)(2-61)(3-30)(4-45)(5-36)(6-32)(7-56)(8-31)(9-34)(10-33)(11-40)(12-42)(13-35)(14-62)(15-41)(16-58)(17-57)(18-43)(19-59)(20-49)(21-37)(22-38)(23-48)(24-47)(25-46)(26-60)(27-39)(28-72)(29-73)(30-31)(30-56)(31-32)(32-66)(33-34)(33-41)(34-67)(35-39)(35-45)(36-38)(36-52)(37-38)(37-50)(39-54)(40-42)(40-43)(41-57)(42-68)(43-59)(44-49)(44-52)(45-55)(46-47)(46-48)(47-69)(48-60)(49-54)(50-51)(50-63)(51-52)(51-53)(53-54)(53-55)(55-65)(56-76)(57-77)(58-64)(58-81)(59-79)(60-80)(61-62)(61-71)(62-81)(63-65)(63-78)(64-70)(64-71)(65-74)(66-72)(66-76)(67-72)(67-77)(68-73)(68-79)(69-73)(69-80)(70-75)(70-78)(74-75)(76-82)(77-82)(78-82)(79-82)(80-82)(81-82)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901/DDP | 53 | — | 10.1002/anie.202006089 | 2020 |
| A549 | 64 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901 | 70 | — | 10.1002/anie.202006089 | 2020 |
| HeLa | 81 | — | 10.1002/anie.202006089 | 2020 |
| A549cisR | 82 | — | 10.1002/anie.202006089 | 2020 |
| HepG2 | 1.1e+02 | — | 10.1002/anie.202006089 | 2020 |
| BEAS-2B | 1.4e+02 | — | 10.1002/anie.202006089 | 2020 |
| BEL-7402 | 1.9e+02 | — | 10.1002/anie.202006089 | 2020 |
| LO2 | 1.9e+02 | — | 10.1002/anie.202006089 | 2020 |
🧬 Cell Death Types (1)
Necroptosis
high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»