Info
| ID | 74 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru1 |
| SMILES | c1cc2ccc3cccc4c5nc(-c6cnccn6)nnc5c(c1)c2c34.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C41H27N9Ru/(1-36)(2-58)(3-59)(4-41)(5-60)(6-47)(7-29)(8-54)(9-37)(10-28)(11-30)(12-31)(13-44)(14-38)(15-43)(16-32)(17-34)(18-35)(19-55)(20-39)(21-56)(22-33)(23-40)(24-42)(25-46)(26-45)(27-57)(28-29)(28-31)(29-61)(30-37)(30-38)(31-54)(32-36)(32-41)(33-35)(33-50)(34-35)(34-48)(36-52)(37-62)(38-55)(39-43)(39-56)(40-47)(40-50)(41-53)(42-45)(42-57)(43-44)(44-64)(45-46)(46-65)(47-52)(48-49)(48-63)(49-50)(49-51)(51-52)(51-53)(53-67)(54-72)(55-73)(56-74)(57-76)(58-66)(58-77)(59-60)(59-69)(60-77)(61-65)(61-72)(62-64)(62-73)(63-67)(63-75)(64-74)(65-76)(66-68)(66-69)(67-70)(68-71)(68-75)(70-71)(72-78)(73-78)(74-78)(75-78)(76-78)(77-78)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SGC-7901 | 1.1e+02 | — | 10.1002/anie.202006089 | 2020 |
| A549 | 1.3e+02 | — | 10.1002/anie.202006089 | 2020 |
| HeLa | 1.4e+02 | — | 10.1002/anie.202006089 | 2020 |
| SGC-7901/DDP | 1.6e+02 | — | 10.1002/anie.202006089 | 2020 |
| A549cisR | 1.8e+02 | — | 10.1002/anie.202006089 | 2020 |
| BEAS-2B | 2e+02 | — | 10.1002/anie.202006089 | 2020 |
| LO2 | — | — | 10.1002/anie.202006089 | 2020 |
| HepG2 | — | — | 10.1002/anie.202006089 | 2020 |
| BEL-7402 | — | — | 10.1002/anie.202006089 | 2020 |
🧬 Cell Death Types (1)
Necroptosis
high
«Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis.»