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Complex #720 — Ru(2) [1]

2D Structure

Structure
⬇ MOL V3000

Info

ID720
MetalRu
Oxidation state2
Charge2
Donor atoms{"N": 6}
Abbreviation1
SMILESCc1ccnc(-c2cc(C)ccn2)c1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1

TUCAN

C60H44N6Ru/(1-47)(2-48)(3-94)(4-49)(5-50)(6-95)(7-54)(8-51)(9-61)(10-52)(11-67)(12-53)(13-60)(14-58)(15-59)(16-62)(17-68)(18-96)(19-56)(20-73)(21-78)(22-45)(23-45)(24-45)(25-93)(26-46)(27-65)(28-63)(29-69)(30-98)(31-64)(32-70)(33-72)(34-75)(35-55)(36-66)(37-71)(38-57)(39-76)(40-77)(41-46)(42-74)(43-97)(44-46)(45-82)(46-87)(47-49)(47-79)(48-50)(48-80)(49-61)(50-84)(51-52)(51-61)(52-79)(53-60)(53-85)(54-81)(54-94)(55-57)(55-88)(56-82)(56-93)(57-90)(58-62)(58-85)(59-65)(59-86)(60-63)(62-63)(64-69)(64-86)(65-66)(66-69)(67-83)(67-95)(68-89)(68-96)(70-72)(70-77)(71-91)(71-98)(72-92)(73-82)(73-100)(74-87)(74-104)(75-76)(75-92)(76-77)(78-87)(78-97)(79-81)(80-81)(80-99)(83-84)(83-85)(84-101)(86-89)(88-89)(88-102)(90-91)(90-103)(91-92)(93-105)(94-106)(95-107)(96-108)(97-110)(98-109)(99-101)(99-106)(100-104)(100-105)(101-107)(102-103)(102-108)(103-109)(104-110)(105-111)(106-111)(107-111)(108-111)(109-111)(110-111)

Measurements (22)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
CT-261.40.06 10.1021/jacs.9b13620 2020
MAgEC 10.52.5— 10.1007/s00775-014-1187-5 2014
CT-263.10.19 10.1021/jacs.9b13620 2020
CT-263.30.34 10.1021/jacs.9b13620 2020
MLuMEC3.4— 10.1007/s00775-014-1187-5 2014
MRC-54.20.27 10.1021/acs.jmedchem.0c02006 2021
MRC-54.20.46 10.1021/acs.jmedchem.0c02006 2021
CT-264.20.2 10.1021/jacs.9b13620 2020
4T14.9— 10.1007/s00775-014-1187-5 2014
T265.30.43 10.1021/acs.inorgchem.3c01984 2023
A5495.5— 10.1007/s00775-014-1187-5 2014
A27808.40.44 10.1021/acs.jmedchem.0c02006 2021
A27808.40.67 10.1021/acs.jmedchem.0c02006 2021
A2780/ADR9.50.55 10.1021/acs.jmedchem.0c02006 2021
A2780/ADR9.50.72 10.1021/acs.jmedchem.0c02006 2021
A2780cisR9.80.51 10.1021/acs.jmedchem.0c02006 2021
A2780cisR9.80.63 10.1021/acs.jmedchem.0c02006 2021
RPE-1100.8 10.1021/acs.inorgchem.3c01984 2023
HeLa140.61 10.1021/jacs.9b13620 2020
U373231.9 10.1021/jacs.9b13620 2020
U-87 MG280.67 10.1021/jacs.9b13620 2020
RPE-1290.83 10.1021/jacs.9b13620 2020

🧬 Cell Death Types (1)

Apoptosis high
«4T1 cells after incubation with ruthenium compounds show marked morphological sign of apoptosis, such as decreasing amount of detached cells, cells rounding and shrinkage... The results suggest that c...»