Info
| ID | 72 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | [Ru(DIP)2(mal)](PF6) |
| SMILES | Cc1occc(=O)c1[O-].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C54H37N4O3Ru/(1-41)(2-42)(3-39)(4-49)(5-80)(6-48)(7-55)(8-45)(9-40)(10-44)(11-43)(12-81)(13-51)(14-57)(15-46)(16-60)(17-58)(18-59)(19-50)(20-53)(21-88)(22-38)(23-62)(24-64)(25-82)(26-54)(27-61)(28-63)(29-52)(30-65)(31-66)(32-47)(33-67)(34-56)(35-83)(36-38)(37-38)(38-89)(39-49)(39-69)(40-41)(40-42)(41-48)(42-55)(43-70)(43-80)(44-45)(44-51)(45-57)(46-53)(46-54)(47-66)(47-67)(48-68)(49-72)(50-71)(50-81)(51-58)(52-75)(52-82)(53-59)(54-61)(55-68)(56-78)(56-83)(57-74)(58-74)(59-76)(60-64)(60-73)(61-76)(62-88)(62-90)(63-66)(63-79)(64-77)(65-67)(65-79)(68-70)(69-70)(69-84)(71-72)(71-74)(72-85)(73-75)(73-86)(75-76)(77-78)(77-87)(78-79)(80-92)(81-93)(82-94)(83-95)(84-85)(84-92)(85-93)(86-87)(86-94)(87-95)(88-98)(89-91)(89-98)(90-91)(90-96)(91-97)(92-99)(93-99)(94-99)(95-99)(98-99)
Measurements (10)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| CT-26 | 0.37 | — | 10.1002/cbic.202200398 | 2022 |
| A2780cisR | 0.42 | — | 10.1002/chem.201904877 | 2020 |
| HeLa | 0.45 | — | 10.1002/chem.201904877 | 2020 |
| CT-26 | 0.61 | — | 10.1002/chem.201904877 | 2020 |
| RPE-1 | 0.67 | — | 10.1002/cbic.202200398 | 2022 |
| CT-26 LUC | 0.72 | — | 10.1002/chem.201904877 | 2020 |
| A2780 | 0.74 | — | 10.1002/chem.201904877 | 2020 |
| RPE-1 | 0.86 | — | 10.1002/chem.201904877 | 2020 |
| PC-3 | 1.8 | — | 10.1002/cbic.202200398 | 2022 |
| A2780/ADR | 2.9 | — | 10.1002/chem.201904877 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Annexin V and PI staining confirmed that [Ru(DIP)2(mal)](PF6) induces mostly apoptotic cell death in treated HeLa cells.»
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