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Complex #72 — Ru(2) [[Ru(DIP)2(mal)](PF6)]

2D Structure

Structure
⬇ MOL V3000

Info

ID72
MetalRu
Oxidation state2
Charge1
Donor atoms{"O": 1, "N": 4}
Abbreviation[Ru(DIP)2(mal)](PF6)
SMILESCc1occc(=O)c1[O-].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1

TUCAN

C54H37N4O3Ru/(1-41)(2-42)(3-39)(4-49)(5-80)(6-48)(7-55)(8-45)(9-40)(10-44)(11-43)(12-81)(13-51)(14-57)(15-46)(16-60)(17-58)(18-59)(19-50)(20-53)(21-88)(22-38)(23-62)(24-64)(25-82)(26-54)(27-61)(28-63)(29-52)(30-65)(31-66)(32-47)(33-67)(34-56)(35-83)(36-38)(37-38)(38-89)(39-49)(39-69)(40-41)(40-42)(41-48)(42-55)(43-70)(43-80)(44-45)(44-51)(45-57)(46-53)(46-54)(47-66)(47-67)(48-68)(49-72)(50-71)(50-81)(51-58)(52-75)(52-82)(53-59)(54-61)(55-68)(56-78)(56-83)(57-74)(58-74)(59-76)(60-64)(60-73)(61-76)(62-88)(62-90)(63-66)(63-79)(64-77)(65-67)(65-79)(68-70)(69-70)(69-84)(71-72)(71-74)(72-85)(73-75)(73-86)(75-76)(77-78)(77-87)(78-79)(80-92)(81-93)(82-94)(83-95)(84-85)(84-92)(85-93)(86-87)(86-94)(87-95)(88-98)(89-91)(89-98)(90-91)(90-96)(91-97)(92-99)(93-99)(94-99)(95-99)(98-99)

Measurements (10)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
CT-260.37 10.1002/cbic.202200398 2022
A2780cisR0.42 10.1002/chem.201904877 2020
HeLa0.45 10.1002/chem.201904877 2020
CT-260.61 10.1002/chem.201904877 2020
RPE-10.67 10.1002/cbic.202200398 2022
CT-26 LUC0.72 10.1002/chem.201904877 2020
A27800.74 10.1002/chem.201904877 2020
RPE-10.86 10.1002/chem.201904877 2020
PC-31.8 10.1002/cbic.202200398 2022
A2780/ADR2.9 10.1002/chem.201904877 2020

🧬 Cell Death Types (1)

Apoptosis high
«Annexin V and PI staining confirmed that [Ru(DIP)2(mal)](PF6) induces mostly apoptotic cell death in treated HeLa cells.»