Info
| ID | 718 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 4, "P": 2} |
| Abbreviation | [Ru(N-P)2(NCS)2] |
| SMILES | [N-]=C=S.[N-]=C=S.c1ccc(P(c2ccccc2)c2cccc3cccnc23)cc1.c1ccc(P(c2ccccc2)c2cccc3cccnc23)cc1 |
TUCAN
C44H32N4P2RuS2/(1-40)(2-37)(3-39)(4-34)(5-43)(6-38)(7-44)(8-41)(9-42)(10-65)(11-46)(12-50)(13-36)(14-35)(15-47)(16-61)(17-66)(18-58)(19-51)(20-48)(21-33)(22-49)(23-54)(24-62)(25-60)(26-57)(27-59)(28-52)(29-53)(30-55)(31-45)(32-56)(33-40)(33-63)(34-40)(34-69)(35-50)(35-63)(36-39)(36-43)(37-39)(37-70)(38-43)(38-70)(41-44)(41-71)(42-48)(42-71)(44-47)(45-55)(45-60)(46-49)(46-73)(47-48)(49-58)(50-65)(51-52)(51-73)(52-58)(53-57)(53-62)(54-61)(54-66)(55-64)(56-59)(56-62)(57-74)(59-74)(60-72)(61-64)(63-67)(64-68)(65-79)(66-80)(67-69)(67-79)(68-72)(68-80)(69-81)(70-81)(71-81)(72-82)(73-82)(74-82)(75-77)(75-83)(76-78)(76-84)(79-85)(80-85)(81-85)(82-85)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 7.6 | — | 10.3897/pharmacia.70.e111410 | 2023 |
| MRC-5 | 5.8e+02 | — | 10.3897/pharmacia.70.e111410 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«This study demonstrated the potent apoptotic activity of ruthenium complex II by determining the activation of caspase-3»