Info
| ID | 7045 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Rh3 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1cc2ccc3ccc(-c4nc5c6cccnc6c6ncccc6c5[nH]4)c4ccc(c1)c2c34 |
TUCAN
C51H32N6Rh/(1-43)(2-44)(3-38)(4-75)(5-54)(6-42)(7-41)(8-47)(9-36)(10-37)(11-45)(12-40)(13-55)(14-48)(15-60)(16-73)(17-53)(18-74)(19-49)(20-35)(21-52)(22-57)(23-50)(24-51)(25-56)(26-61)(27-39)(28-76)(29-58)(30-59)(31-46)(32-85)(33-36)(33-63)(34-61)(34-64)(35-41)(35-71)(36-43)(37-43)(37-44)(38-40)(38-45)(39-46)(39-59)(40-75)(41-72)(42-48)(42-62)(44-63)(45-79)(46-61)(47-58)(47-60)(48-53)(49-57)(49-62)(50-56)(50-73)(51-55)(51-65)(52-54)(52-74)(53-71)(54-70)(55-67)(56-66)(57-65)(58-76)(59-64)(60-82)(62-68)(63-79)(64-82)(65-69)(66-80)(66-81)(67-72)(67-83)(68-69)(68-71)(69-72)(70-77)(70-78)(73-84)(74-87)(75-88)(76-89)(77-81)(77-86)(78-80)(78-87)(79-88)(80-84)(81-85)(82-89)(83-85)(83-86)(86-90)(87-90)(88-90)(89-90)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 1.4 | — | 10.1039/d1dt01053k | 2021 |
| HeLa | 1.4 | — | 10.1039/d1dt01053k | 2021 |
| HLF | 2.6 | — | 10.1039/d1dt01053k | 2021 |
| A549 | 5.5 | — | 10.1039/d1dt01053k | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further studies illustrated that the rhodium complexes caused cell cycle arrest at the G2/M phase, upregulated the expression of p53 and reduced the ratio of B-cell lymphoma-2 (Bcl-2)/Bcl-2-associated...»