Info
| ID | 7044 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | Rh2 |
| SMILES | [c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc2c(-c3nc4c5cccnc5c5ncccc5c4[nH]3)c3ccccc3cc2c1 |
TUCAN
C49H32N6Rh/(1-45)(2-58)(3-46)(4-72)(5-49)(6-35)(7-48)(8-37)(9-38)(10-57)(11-71)(12-44)(13-56)(14-59)(15-73)(16-54)(17-53)(18-42)(19-52)(20-36)(21-50)(22-55)(23-43)(24-51)(25-39)(26-61)(27-74)(28-41)(29-40)(30-60)(31-47)(32-83)(33-37)(33-65)(34-60)(34-70)(35-44)(35-66)(36-53)(36-72)(37-45)(38-45)(38-58)(39-46)(39-73)(40-47)(40-61)(41-48)(41-74)(42-49)(42-62)(43-50)(43-71)(44-49)(46-57)(47-60)(48-59)(50-68)(51-55)(51-56)(52-66)(52-67)(53-63)(54-56)(54-67)(55-69)(57-76)(58-65)(59-80)(61-70)(62-64)(62-66)(63-75)(63-78)(64-69)(64-81)(65-76)(67-69)(68-77)(68-79)(70-80)(71-85)(72-82)(73-84)(74-87)(75-79)(75-83)(76-84)(77-78)(77-85)(78-82)(79-86)(80-87)(81-83)(81-86)(84-88)(85-88)(86-88)(87-88)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 0.37 | — | 10.1039/d1dt01053k | 2021 |
| A549 | 0.71 | — | 10.1039/d1dt01053k | 2021 |
| MDA-MB-231 | 1.1 | — | 10.1039/d1dt01053k | 2021 |
| HLF | 3.5 | — | 10.1039/d1dt01053k | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further studies illustrated that the rhodium complexes caused cell cycle arrest at the G2/M phase, upregulated the expression of p53 and reduced the ratio of B-cell lymphoma-2 (Bcl-2)/Bcl-2-associated...»