Info
| ID | 7030 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 5} |
| Abbreviation | 1b |
| SMILES | Cn1nc(-c2cccc(-c3nn(C)c4c3[C@H]3CC[C@]4(C)C3(C)C)n2)c2c1[C@]1(C)CC[C@H]2C1(C)C.[Cl-].[Cl-].[Cl-] |
TUCAN
C29H37N5Rh/(1-40)(2-38)(3-38)(4-53)(5-47)(6-49)(7-54)(8-49)(9-47)(10-38)(11-39)(12-39)(13-40)(14-50)(15-39)(16-42)(17-48)(18-40)(19-41)(20-59)(21-42)(22-59)(23-44)(24-42)(25-41)(26-50)(27-43)(28-59)(29-41)(30-48)(31-43)(32-43)(33-45)(34-46)(35-60)(36-60)(37-60)(38-55)(39-55)(40-56)(41-58)(42-57)(43-57)(44-45)(44-62)(45-46)(46-65)(47-49)(47-56)(48-50)(48-58)(49-53)(50-54)(51-53)(51-61)(51-63)(52-54)(52-64)(52-66)(53-55)(54-57)(55-56)(56-63)(57-58)(58-64)(59-68)(60-69)(61-62)(61-70)(62-67)(63-68)(64-69)(65-66)(65-67)(66-71)(68-70)(69-71)(70-72)(71-72)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 7.3 | — | 10.1021/acs.inorgchem.8b02390 | 2018 |
| HCT-116 | 80 | — | 10.1021/acs.inorgchem.8b02390 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that complex 1b induces apoptosis. However, the MTT assay shows significant cytotoxic activity with IC50 values of 80.01 μM (24h) and 7.26 μM (72h) against HCT-11...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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