Info
| ID | 7029 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2, "S": 1, "O": 1} |
| Abbreviation | Rh2 |
| SMILES | COc1ccc2c(c1)CCN=C2c1ccccc1N.CS(C)=O.[Cl-].[Cl-].[Cl-] |
TUCAN
C18H22N2O2RhS/(1-39)(2-34)(3-24)(4-28)(5-29)(6-34)(7-23)(8-39)(9-27)(10-30)(11-25)(12-26)(13-30)(14-39)(15-37)(16-37)(17-40)(18-40)(19-40)(20-37)(21-41)(22-41)(23-29)(23-31)(24-33)(24-38)(25-26)(25-38)(26-32)(27-28)(27-36)(28-29)(30-33)(30-34)(31-35)(31-36)(32-33)(32-35)(34-42)(35-42)(36-41)(37-44)(38-44)(39-45)(40-45)(42-46)(43-45)(44-46)(45-46)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 10 | — | 10.1039/c9dt01951k | 2019 |
| A549 | 30 | — | 10.1039/c9dt01951k | 2019 |
| HL-7702 | 53 | — | 10.1039/c9dt01951k | 2019 |
| HeLa | 59 | — | 10.1039/c9dt01951k | 2019 |
| MGC-803 | 66 | — | 10.1039/c9dt01951k | 2019 |
| BEL-7704 | 70 | — | 10.1039/c9dt01951k | 2019 |
| SK-OV-3 | — | — | 10.1039/c9dt01951k | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«These complexes triggered apoptosis via mitochondrial dysfunction that increased the levels of ROS and Ca2+ and released cytochrome C which ultimately activated caspases and the apoptosis pathway.»