Info
| ID | 7028 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 2, "S": 1, "O": 1} |
| Abbreviation | Rh1 |
| SMILES | COc1cc2c(cc1OC)C(c1ccccc1N)=NCC2.CS(C)=O.[Cl-].[Cl-].[Cl-] |
TUCAN
C19H24N2O3RhS/(1-31)(2-42)(3-39)(4-27)(5-26)(6-25)(7-42)(8-31)(9-35)(10-39)(11-29)(12-30)(13-39)(14-35)(15-42)(16-43)(17-28)(18-38)(19-38)(20-43)(21-43)(22-38)(23-44)(24-44)(25-28)(25-32)(26-27)(26-37)(27-28)(29-33)(29-40)(30-34)(30-41)(31-33)(31-35)(32-36)(32-37)(33-34)(34-36)(35-45)(36-45)(37-44)(38-47)(39-48)(40-41)(40-47)(41-48)(42-49)(43-49)(45-50)(46-49)(47-50)(48-50)(49-50)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 4.1 | — | 10.1039/c9dt01951k | 2019 |
| BEL-7704 | 18 | — | 10.1039/c9dt01951k | 2019 |
| HeLa | 22 | — | 10.1039/c9dt01951k | 2019 |
| HL-7702 | 35 | — | 10.1039/c9dt01951k | 2019 |
| SK-OV-3 | 44 | — | 10.1039/c9dt01951k | 2019 |
| MGC-803 | 62 | — | 10.1039/c9dt01951k | 2019 |
| A549 | 75 | — | 10.1039/c9dt01951k | 2019 |
🧬 Cell Death Types (1)
Apoptosis
high
«These complexes triggered apoptosis via mitochondrial dysfunction that increased the levels of ROS and Ca2+ and released cytochrome C which ultimately activated caspases and the apoptosis pathway.»