Info
| ID | 7019 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"S": 2, "O": 3, "N": 1} |
| Abbreviation | 1 |
| SMILES | CS(C)=O.CS(C)=O.Cc1ccc2cccc([O-])c2n1.[Cl-].[Cl-] |
TUCAN
C14H20NO3RhS2/(1-21)(2-22)(3-21)(4-26)(5-31)(6-31)(7-31)(8-32)(9-32)(10-32)(11-24)(12-23)(13-33)(14-33)(15-25)(16-21)(17-33)(18-34)(19-34)(20-34)(21-29)(22-24)(22-30)(23-25)(23-27)(24-26)(25-29)(26-27)(27-28)(28-30)(28-35)(29-35)(30-36)(31-39)(32-39)(33-40)(34-40)(35-41)(37-39)(38-40)(39-41)(40-41)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 6.5 | — | 10.1039/c6md00462h | 2017 |
| T24 | 9.9 | — | 10.1039/c6md00462h | 2017 |
| BEL-7404 | 10 | — | 10.1039/c6md00462h | 2017 |
| A549 | 15 | — | 10.1039/c6md00462h | 2017 |
| NCI-H460 | 18 | — | 10.1039/c6md00462h | 2017 |
| HL-7702 | 29 | — | 10.1039/c6md00462h | 2017 |
🧬 Cell Death Types (1)
Apoptosis
high
«cytotoxicity mechanism studies suggested that complex 1-induced apoptosis was achieved via disruption of the mitochondrial function, which led to a significant loss of the mitochondrial membrane poten...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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