Info
| ID | 7010 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Rh2 |
| SMILES | Cc1ccc(N(c2ccc(C)cc2)c2ccc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2)cc1.[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1 |
TUCAN
C55H41N7Rh/(1-55)(2-50)(3-57)(4-52)(5-85)(6-66)(7-58)(8-61)(9-68)(10-48)(11-71)(12-83)(13-53)(14-63)(15-64)(16-65)(17-86)(18-56)(19-46)(20-49)(21-60)(22-84)(23-42)(24-42)(25-72)(26-42)(27-75)(28-69)(29-54)(30-59)(31-70)(32-43)(33-67)(34-43)(35-43)(36-74)(37-62)(38-51)(39-73)(40-47)(41-98)(42-79)(43-82)(44-66)(44-76)(45-71)(45-77)(46-53)(46-87)(47-70)(47-88)(48-53)(48-83)(49-50)(49-52)(50-66)(51-54)(51-65)(52-76)(54-77)(55-58)(55-89)(56-63)(56-80)(57-62)(57-84)(58-79)(59-61)(59-81)(60-68)(60-89)(61-85)(62-78)(63-92)(64-70)(64-86)(65-71)(67-72)(67-94)(68-79)(69-73)(69-92)(72-82)(73-80)(74-75)(74-94)(75-82)(76-87)(77-88)(78-90)(78-93)(80-96)(81-91)(81-95)(83-100)(84-97)(85-101)(86-102)(87-100)(88-102)(89-99)(90-91)(90-98)(91-103)(92-99)(93-95)(93-97)(94-99)(95-101)(96-98)(96-103)(100-104)(101-104)(102-104)(103-104)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 1.6 | — | 10.1016/j.jinorgbio.2021.11140... | 2021 |
| HeLa | 2.1 | — | 10.1016/j.jinorgbio.2021.11140... | 2021 |
| A549 | 3 | — | 10.1016/j.jinorgbio.2021.11140... | 2021 |
| MCF-10A | 8.8 | — | 10.1016/j.jinorgbio.2021.11140... | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further mechanism studies show that Rh1 induce caspase-dependent apoptosis through mitochondrial damage, down-regulate the expression of B-cell lymphoma-2 (Bcl-2)/Bcl2-associated x (Bax) and reactive ...»
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