Info
| ID | 70 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | 1 |
| SMILES | COc1cc(/C=C/C(=O)/C=C([O-])/C=C/c2ccc(O)c(OC)c2)ccc1O.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C41H35N4O6Ru/(1-61)(2-36)(3-69)(4-37)(5-38)(6-69)(7-39)(8-69)(9-40)(10-62)(11-44)(12-42)(13-46)(14-43)(15-50)(16-54)(17-70)(18-70)(19-70)(20-56)(21-45)(22-48)(23-47)(24-53)(25-49)(26-58)(27-51)(28-63)(29-64)(30-55)(31-57)(32-41)(33-52)(34-83)(35-84)(36-37)(36-39)(37-65)(38-40)(38-66)(39-61)(40-42)(41-48)(41-67)(42-62)(43-46)(43-59)(44-60)(44-73)(45-51)(45-71)(46-72)(47-48)(47-63)(49-53)(49-64)(50-59)(50-75)(51-60)(52-53)(52-68)(54-72)(54-74)(55-56)(55-60)(56-74)(57-58)(57-59)(58-76)(61-77)(62-78)(63-79)(64-80)(65-66)(65-77)(66-78)(67-68)(67-79)(68-80)(69-85)(70-86)(71-73)(71-83)(72-82)(73-85)(74-81)(75-76)(75-86)(76-84)(77-87)(78-87)(79-87)(80-87)(86-87)
Measurements (12)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| DU-145 | 0.29 | — | 10.1002/ejic.202100468 | 2021 |
| HL60 | 0.38 | 0.34 | 10.1002/ejic.202100468 | 2021 |
| MIA PaCa-2 | 0.77 | — | 10.1002/ejic.202100468 | 2021 |
| MIA PaCa-2 | 1.4 | — | 10.1002/chem.202403695 | 2025 |
| MIA PaCa-2 | 1.6 | 0.66 | 10.1002/chem.202403695 | 2025 |
| MDA-MB-231 | 1.9 | 1.4 | 10.1002/chem.202403695 | 2025 |
| MDA-MB-231 | 2.3 | — | 10.1002/chem.202403695 | 2025 |
| PANC-1 | 2.3 | — | 10.1002/chem.202403695 | 2025 |
| PANC-1 | 3.7 | 1.3 | 10.1002/chem.202403695 | 2025 |
| A549 | 3.8 | — | 10.1039/D0DT01040E | 2020 |
| MCF-7 | 5.2 | — | 10.1039/D0DT01040E | 2020 |
| SGC-7901 | 5.8 | — | 10.1039/D0DT01040E | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 2 induces apoptosis via the intrinsic pathway»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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