Info
| ID | 6999 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | Rh4 |
| SMILES | CO.O=C([N-]c1ccccc1)c1nc(-n2nc(C(F)(F)F)cc2C(F)(F)F)ccc1Cl.[Cl-].[Cl-] |
TUCAN
C18H12ClF6N4O2Rh/(1-14)(2-15)(3-17)(4-18)(5-20)(6-13)(7-16)(8-19)(9-26)(10-26)(11-26)(12-36)(13-22)(13-24)(14-15)(14-21)(15-17)(16-18)(16-21)(17-18)(19-20)(19-30)(20-25)(21-33)(22-28)(22-32)(23-27)(23-30)(23-34)(24-29)(24-31)(25-32)(25-34)(26-36)(27-33)(27-35)(28-40)(28-41)(28-42)(29-37)(29-38)(29-39)(30-43)(31-32)(33-44)(34-44)(36-44)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 21 | — | 10.1021/acs.jmedchem.3c00318 | 2023 |
| A549 | — | — | 10.1021/acs.jmedchem.3c00318 | 2023 |
| BEL-7404 | — | — | 10.1021/acs.jmedchem.3c00318 | 2023 |
| HeLa | — | — | 10.1021/acs.jmedchem.3c00318 | 2023 |
| SK-OV-3 | — | — | 10.1021/acs.jmedchem.3c00318 | 2023 |
| WI-38 | — | — | 10.1021/acs.jmedchem.3c00318 | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«The mechanism study indicated that Rh1 and Rh2 inhibited cell proliferation by multiple modes of action via cell cycle arrest, apoptosis, and autophagy»
Autophagy
high
«The mechanism study indicated that Rh1 and Rh2 inhibited cell proliferation by multiple modes of action via cell cycle arrest, apoptosis, and autophagy»