Info
| ID | 6957 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 3, "O": 1} |
| Abbreviation | Rh-2 |
| SMILES | CC(C)(C)c1cccc2cc(-c3nc4ccccc4[nH]3)c(=N)oc12.CO.[Cl-].[Cl-].[Cl-] |
TUCAN
C21H23N3O2Rh/(1-24)(2-31)(3-24)(4-27)(5-24)(6-25)(7-25)(8-28)(9-25)(10-30)(11-34)(12-42)(13-32)(14-29)(15-26)(16-26)(17-26)(18-33)(19-42)(20-42)(21-46)(22-45)(23-48)(24-38)(25-38)(26-38)(27-28)(27-35)(28-29)(29-36)(30-35)(30-37)(31-33)(31-39)(32-33)(32-34)(34-40)(35-43)(36-38)(36-43)(37-41)(37-44)(39-40)(39-47)(40-45)(41-45)(41-47)(42-48)(43-49)(44-46)(44-49)(46-50)(47-50)(48-50)(49-50)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549cisR | 3.2 | — | 10.1016/j.inoche.2020.108017 | 2020 |
| SK-OV-3cisR | 5.5 | — | 10.1016/j.inoche.2020.108017 | 2020 |
| HL-7702 | 86 | — | 10.1016/j.inoche.2020.108017 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«This suggested that cell death was induced by Rh-2 (3.21μM) and Rh-3 (0.50μM) via a high incidence of apoptosis. ... These results suggested that Rh-2 (3.21μM) and Rh-3 (0.50μM) could induce apoptosis...»