Info
| ID | 69 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru10 |
| SMILES | CC#N.CC#N.CC[n+]1[c-]n(-c2ccccn2)cc1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C26H25N7Ru/(1-28)(2-31)(3-26)(4-26)(5-26)(6-28)(7-44)(8-28)(9-32)(10-36)(11-29)(12-47)(13-46)(14-45)(15-27)(16-42)(17-30)(18-37)(19-35)(20-47)(21-34)(22-43)(23-33)(24-27)(25-27)(26-40)(27-41)(28-47)(29-31)(29-44)(30-33)(30-45)(31-38)(32-36)(32-38)(33-39)(34-35)(34-37)(35-51)(36-39)(37-46)(38-48)(39-49)(40-52)(41-53)(42-43)(42-54)(43-55)(44-57)(45-58)(46-56)(47-54)(48-49)(48-57)(49-58)(50-54)(50-55)(51-55)(51-56)(56-59)(57-59)(58-59)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 4.7 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 12 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 16 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 18 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | 20 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 23 | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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