Info
| ID | 6893 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 5} |
| Abbreviation | Rh4 |
| SMILES | CC1(C)[C@@H]2CC[C@@]1(C)c1[nH]nc(-c3cccc(-c4n[nH]c5c4[C@H]4CC[C@]5(C)C4(C)C)n3)c12.[Cl-].[Cl-].[Cl-] |
TUCAN
C27H33N5Rh/(1-35)(2-49)(3-35)(4-40)(5-34)(6-34)(7-44)(8-50)(9-34)(10-35)(11-36)(12-36)(13-43)(14-43)(15-44)(16-46)(17-45)(18-37)(19-36)(20-38)(21-37)(22-41)(23-45)(24-37)(25-46)(26-38)(27-38)(28-39)(29-39)(30-42)(31-39)(32-62)(33-63)(34-51)(35-52)(36-52)(37-53)(38-54)(39-54)(40-41)(40-58)(41-42)(42-60)(43-44)(43-51)(44-49)(45-46)(45-53)(46-50)(47-49)(47-55)(47-56)(48-50)(48-57)(48-59)(49-52)(50-54)(51-52)(51-56)(53-54)(53-59)(55-58)(55-64)(56-62)(57-60)(57-65)(58-61)(59-63)(60-61)(62-64)(63-65)(64-66)(65-66)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 7.6 | — | 10.1021/acs.jmedchem.4c01220 | 2024 |
| MRC-5 | 8.7 | — | 10.1021/acs.jmedchem.4c01220 | 2024 |
| HCT-116 | — | — | 10.1021/acs.inorgchem.8b02390 | 2018 |
| HCT-116 | — | — | 10.1021/acs.inorgchem.8b02390 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
low
«The article does not explicitly state that complex 1b induces apoptosis. However, the MTT assay shows significant cytotoxic activity with IC50 values of 80.01 μM (24h) and 7.26 μM (72h) against HCT-11...»