Info
| ID | 6889 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"N": 7} |
| Abbreviation | 5 |
| SMILES | CC#N.Cc1cc(-c2ccccc2)n2nc3nc(-n4nc(C)cc4-c4ccccc4)cc(C)c3c2n1.[Cl-].[Cl-].[Cl-] |
TUCAN
C29H25N7Rh/(1-41)(2-30)(3-29)(4-29)(5-29)(6-39)(7-27)(8-28)(9-42)(10-26)(11-26)(12-34)(13-26)(14-32)(15-31)(16-33)(17-28)(18-27)(19-28)(20-40)(21-27)(22-37)(23-38)(24-36)(25-35)(26-44)(27-49)(28-51)(29-47)(30-34)(30-35)(31-44)(31-53)(32-34)(32-43)(33-35)(33-43)(36-48)(36-51)(37-49)(37-50)(38-41)(38-42)(39-41)(39-46)(40-42)(40-46)(43-48)(44-45)(45-52)(45-54)(46-50)(47-55)(48-58)(49-56)(50-59)(51-57)(52-56)(52-59)(53-58)(53-60)(54-60)(54-61)(57-58)(59-61)(60-62)(61-62)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 2.1 | — | 10.1016/j.bioorg.2023.106838 | 2023 |
| HL-7702 | 2.5 | — | 10.1016/j.bioorg.2023.106838 | 2023 |
| WI-38 | 3.2 | — | 10.1016/j.bioorg.2023.106838 | 2023 |
| HeLa | 4.2 | — | 10.1016/j.bioorg.2023.106838 | 2023 |
| A549 | 4.5 | — | 10.1016/j.bioorg.2023.106838 | 2023 |
| BEL-7404 | 5.7 | — | 10.1016/j.bioorg.2023.106838 | 2023 |
| SK-OV-3 | 5.8 | — | 10.1016/j.bioorg.2023.106838 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanism studies indicated that complexes 5 and 6 induced G2/M phase cell cycle arrest through DNA damage, and induced apoptosis via endoplasmic reticulum stress response. In addition, complex 5 also...»
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