Info
| ID | 6877 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1, "P": 2} |
| Abbreviation | GUPT1 |
| SMILES | [Cl-].[Cl-].[O-]c1cccc2cccnc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C45H36NOP2Rh/(1-38)(2-37)(3-41)(4-43)(5-40)(6-46)(7-42)(8-44)(9-47)(10-54)(11-48)(12-50)(13-52)(14-45)(15-55)(16-49)(17-51)(18-73)(19-69)(20-39)(21-53)(22-57)(23-58)(24-61)(25-64)(26-60)(27-59)(28-62)(29-66)(30-63)(31-70)(32-67)(33-71)(34-68)(35-56)(36-65)(37-38)(37-44)(38-76)(39-69)(39-72)(40-41)(40-76)(41-44)(42-43)(42-77)(43-47)(45-46)(45-77)(46-47)(48-49)(48-54)(49-78)(50-51)(50-54)(51-78)(52-57)(52-59)(53-56)(53-72)(55-58)(55-59)(56-65)(57-79)(58-79)(60-61)(60-63)(61-80)(62-63)(62-64)(64-80)(65-75)(66-67)(66-70)(67-68)(68-71)(69-73)(70-81)(71-81)(72-74)(73-82)(74-75)(74-82)(75-83)(76-84)(77-84)(78-84)(79-85)(80-85)(81-85)(82-86)(84-86)(85-86)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549cisR | 15 | — | 10.1016/j.bioorg.2025.108789 | 2025 |
| A549 | 25 | — | 10.1016/j.bioorg.2025.108789 | 2025 |
| HEK293 | — | — | 10.1016/j.bioorg.2025.108789 | 2025 |
🧬 Cell Death Types (2)
Apoptosis
high
«GUPT3 and GUPT4 induce CR-A549 mitochondrial autophagy and ATP blockade, leading to apoptosis.»
Autophagy
high
«GUPT3 and GUPT4 induce CR-A549 mitochondrial autophagy and ATP blockade, leading to apoptosis.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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