Info
| ID | 6857 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 2, "N": 2, "P": 1} |
| Abbreviation | YNU-1c |
| SMILES | Cc1ccc2c(Cl)cc(Cl)c([O-])c2n1.Cc1ccc2c(Cl)cc(Cl)c([O-])c2n1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38H27Cl4N2O2PRh/(1-36)(2-33)(3-37)(4-38)(5-30)(6-31)(7-39)(8-35)(9-28)(10-50)(11-41)(12-32)(13-34)(14-46)(15-47)(16-44)(17-43)(18-28)(19-48)(20-45)(21-40)(22-42)(23-28)(24-29)(25-29)(26-29)(27-49)(28-53)(29-56)(30-33)(30-38)(31-37)(31-38)(32-39)(32-40)(33-59)(34-40)(34-41)(35-43)(35-51)(36-62)(36-63)(37-59)(39-60)(41-60)(42-44)(42-45)(43-53)(44-46)(45-47)(46-61)(47-61)(48-50)(48-56)(49-64)(49-65)(50-52)(51-54)(51-63)(52-55)(52-64)(53-66)(54-57)(54-66)(55-58)(55-67)(56-67)(57-62)(57-68)(58-65)(58-69)(59-70)(60-70)(61-70)(62-72)(63-71)(64-73)(65-74)(66-75)(67-75)(70-75)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCC1806 | 0.13 | — | 10.1016/j.ejmech.2024.116478 | 2024 |
| HepG2 | 0.19 | — | 10.1016/j.ejmech.2024.116478 | 2024 |
| HL-7702 | — | — | 10.1016/j.ejmech.2024.116478 | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«YNU-1b and YNU-1c induced the activation of apoptotic pathways ... released cytochrome c, cleaved caspase-3/pro-caspase-3 ... TUNEL revealed that HCC1806 tumor tissues exhibited significant apoptotic ...»
Autophagy
high
«YNU-1b and YNU-1c induced the activation of ... mitophagy (a selective form of autophagy). The title also specifies 'targeting mitophagy pathways'.»