Info
| ID | 6856 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 2, "N": 2, "P": 1} |
| Abbreviation | YNU-1b |
| SMILES | [Cl-].[O-]c1c(Cl)cc(Cl)c2cccnc12.[O-]c1c(Cl)cc(Cl)c2cccnc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H23Cl4N2O2PRh/(1-25)(2-30)(3-26)(4-24)(5-29)(6-47)(7-31)(8-33)(9-27)(10-41)(11-42)(12-28)(13-35)(14-38)(15-37)(16-39)(17-32)(18-34)(19-36)(20-48)(21-40)(22-43)(23-44)(24-25)(24-53)(25-30)(26-29)(26-30)(27-31)(27-32)(28-32)(28-33)(29-53)(31-54)(33-54)(34-38)(34-39)(35-37)(35-47)(36-56)(36-57)(37-45)(38-41)(39-42)(40-43)(40-48)(41-55)(42-55)(43-46)(44-58)(44-59)(45-49)(45-56)(46-50)(46-59)(47-60)(48-61)(49-51)(49-60)(50-52)(50-61)(51-57)(51-62)(52-58)(52-63)(53-64)(54-64)(55-64)(56-66)(57-65)(58-68)(59-67)(60-69)(61-69)(64-69)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCC1806 | 0.47 | — | 10.1016/j.ejmech.2024.116478 | 2024 |
| HepG2 | 0.59 | — | 10.1016/j.ejmech.2024.116478 | 2024 |
| HL-7702 | — | — | 10.1016/j.ejmech.2024.116478 | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«YNU-1b and YNU-1c induced the activation of apoptotic pathways ... released cytochrome c, cleaved caspase-3/pro-caspase-3 ... TUNEL revealed that HCC1806 tumor tissues exhibited significant apoptotic ...»
Autophagy
high
«YNU-1b and YNU-1c induced the activation of ... mitophagy (a selective form of autophagy). The title also specifies 'targeting mitophagy pathways'.»