Info
| ID | 6855 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 2, "N": 2, "P": 1} |
| Abbreviation | YNU-1a |
| SMILES | Cc1ccc2cccc([O-])c2n1.Cc1ccc2cccc([O-])c2n1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38H31N2O2PRh/(1-32)(2-40)(3-39)(4-36)(5-34)(6-42)(7-35)(8-41)(9-56)(10-46)(11-37)(12-48)(13-45)(14-51)(15-49)(16-54)(17-58)(18-38)(19-47)(20-50)(21-52)(22-32)(23-53)(24-55)(25-32)(26-57)(27-44)(28-33)(29-33)(30-33)(31-43)(32-62)(33-63)(34-39)(34-40)(35-39)(35-42)(36-56)(36-59)(37-38)(37-59)(38-62)(40-67)(41-45)(41-48)(42-67)(43-44)(43-63)(44-60)(45-68)(46-48)(46-51)(47-49)(47-52)(49-50)(50-53)(51-68)(52-69)(53-69)(54-56)(54-65)(55-57)(55-66)(57-58)(58-60)(59-61)(60-64)(61-65)(61-70)(62-70)(63-71)(64-66)(64-71)(65-72)(66-73)(67-74)(68-74)(69-74)(70-75)(71-75)(74-75)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCC1806 | 3 | — | 10.1016/j.ejmech.2024.116478 | 2024 |
| HepG2 | 3.7 | — | 10.1016/j.ejmech.2024.116478 | 2024 |
| HL-7702 | — | — | 10.1016/j.ejmech.2024.116478 | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«YNU-1b and YNU-1c induced the activation of apoptotic pathways ... released cytochrome c, cleaved caspase-3/pro-caspase-3 ... TUNEL revealed that HCC1806 tumor tissues exhibited significant apoptotic ...»
Autophagy
high
«YNU-1b and YNU-1c induced the activation of ... mitophagy (a selective form of autophagy). The title also specifies 'targeting mitophagy pathways'.»