Info
| ID | 6817 |
| Metal | Rh |
| Oxidation state | 3 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 3} |
| Abbreviation | 10 |
| SMILES | CCO.Cc1ccc2[nH]c(=O)c(-c3nc4cc(C)c(C)cc4[nH]3)cc2c1.[Cl-].[Cl-].[Cl-] |
TUCAN
C21H23N3O2Rh/(1-26)(2-30)(3-24)(4-33)(5-28)(6-26)(7-31)(8-25)(9-25)(10-24)(11-29)(12-24)(13-25)(14-26)(15-32)(16-43)(17-43)(18-27)(19-27)(20-27)(21-46)(22-45)(23-49)(24-34)(25-35)(26-37)(27-43)(28-37)(28-39)(29-32)(29-34)(30-34)(30-36)(31-36)(31-38)(32-41)(33-35)(33-40)(35-37)(36-41)(38-42)(38-44)(39-40)(39-45)(40-47)(41-46)(42-45)(42-47)(43-49)(44-46)(44-48)(47-50)(49-50)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H460 | 8.2 | — | 10.1016/j.ejmech.2018.03.074 | 2018 |
| HepG2 | 8.8 | — | 10.1016/j.ejmech.2018.03.074 | 2018 |
| MGC-803 | 9.4 | — | 10.1016/j.ejmech.2018.03.074 | 2018 |
| HeLa229 | 10 | — | 10.1016/j.ejmech.2018.03.074 | 2018 |
| HL-7702 | 14 | — | 10.1016/j.ejmech.2018.03.074 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«complex 9 caused cell cycle arrest at the G2/M phase and induced apoptosis (abstract). Also: 'Therefore, complex 9 is a potent apoptosis inducer' (section 2.9) and 'Hence, complex 9 induced cell apopt...»